N-Alkylation of aromatic amines with alcohols by using a commercially available Ru complex under mild conditions

An N-alkylation procedure has been developed under very mild conditions using a known commercially available Ru-based catalyst. As a result, a wide range of aromatic primary amines has been selectively alkylated with several primary alcohols, yielding the corresponding secondary amines in high yield...

Descripción completa

Detalles Bibliográficos
Autores principales: Mocci, Rita, Atzori, Luciano, Baratta, Walter, De Luca, Lidia, Porcheddu, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688395/
https://www.ncbi.nlm.nih.gov/pubmed/38035248
http://dx.doi.org/10.1039/d3ra06751c
Descripción
Sumario:An N-alkylation procedure has been developed under very mild conditions using a known commercially available Ru-based catalyst. As a result, a wide range of aromatic primary amines has been selectively alkylated with several primary alcohols, yielding the corresponding secondary amines in high yields. The methodology also enables the methylation of anilines in refluxing methanol and the preparation of a set of heterocycles in a straightforward way.

Ejemplares similares