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Thyroid function and opium use disorder: a cross-sectional study on the Fasa adults cohort study (FACS), 2017
BACKGROUND: Addiction increases the risk of different lifelong disorders. However, there are limited studies evaluating the effects of opioid use disorder (OUD) on thyroid function. The present study aimed to compare the thyroid function of individuals with and without OUD. METHODS: This cross-secti...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688461/ https://www.ncbi.nlm.nih.gov/pubmed/38031024 http://dx.doi.org/10.1186/s12902-023-01467-3 |
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author | Pezeshki, Babak Pourmontaseri, Hossein Homayounfar, Reza Moghaddam, Maryam Talebi Dehghan, Azizallah |
author_facet | Pezeshki, Babak Pourmontaseri, Hossein Homayounfar, Reza Moghaddam, Maryam Talebi Dehghan, Azizallah |
author_sort | Pezeshki, Babak |
collection | PubMed |
description | BACKGROUND: Addiction increases the risk of different lifelong disorders. However, there are limited studies evaluating the effects of opioid use disorder (OUD) on thyroid function. The present study aimed to compare the thyroid function of individuals with and without OUD. METHODS: This cross-sectional study was conducted on 700 eligible participants of the Persian Cohort of Fasa, Iran. Pregnant women and participants with false or missing data were excluded from the study. Remained participants were divided into case and control groups based on the recorded history of OUD. Frozen plasma samples of the cohort bank were used to determine the levels of T3, T4, and thyroid-stimulating hormone (TSH). The thyroid function was compared between the two groups using the Mann-Whitney test (P < 0.05). RESULTS: The mean age of the final studied population (n = 648) was 54.0 ± 9.8 years, including 336 men (49.1%) and 197 participants with OUD (28.8%). The median levels of TSH, T4, and T3 were 2.91 ± 4.61, 9.26 ± 3.65, and 1.22 ± 0.49, respectively. The case group had significantly higher TSH (3.72 ± 6.2 vs. 2.58 ± 3.75, P < 0.001) and lower T4 (8 ± 3.6 vs. 9.8 ± 3.5, P < 0.001). Also, T3 was slightly lower in the case group (1.1 ± 0.5 vs. 1.3 ± 0.5; P = 0.369), although this association was only significant in female opium users (P < 0.001). CONCLUSIONS: The present findings revealed that OUD caused a reduction in T4 while increasing TSH. Therefore, OUD may lead to the development of primary hypothyroidism, which needs to be investigated in future studies. |
format | Online Article Text |
id | pubmed-10688461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-106884612023-11-30 Thyroid function and opium use disorder: a cross-sectional study on the Fasa adults cohort study (FACS), 2017 Pezeshki, Babak Pourmontaseri, Hossein Homayounfar, Reza Moghaddam, Maryam Talebi Dehghan, Azizallah BMC Endocr Disord Research BACKGROUND: Addiction increases the risk of different lifelong disorders. However, there are limited studies evaluating the effects of opioid use disorder (OUD) on thyroid function. The present study aimed to compare the thyroid function of individuals with and without OUD. METHODS: This cross-sectional study was conducted on 700 eligible participants of the Persian Cohort of Fasa, Iran. Pregnant women and participants with false or missing data were excluded from the study. Remained participants were divided into case and control groups based on the recorded history of OUD. Frozen plasma samples of the cohort bank were used to determine the levels of T3, T4, and thyroid-stimulating hormone (TSH). The thyroid function was compared between the two groups using the Mann-Whitney test (P < 0.05). RESULTS: The mean age of the final studied population (n = 648) was 54.0 ± 9.8 years, including 336 men (49.1%) and 197 participants with OUD (28.8%). The median levels of TSH, T4, and T3 were 2.91 ± 4.61, 9.26 ± 3.65, and 1.22 ± 0.49, respectively. The case group had significantly higher TSH (3.72 ± 6.2 vs. 2.58 ± 3.75, P < 0.001) and lower T4 (8 ± 3.6 vs. 9.8 ± 3.5, P < 0.001). Also, T3 was slightly lower in the case group (1.1 ± 0.5 vs. 1.3 ± 0.5; P = 0.369), although this association was only significant in female opium users (P < 0.001). CONCLUSIONS: The present findings revealed that OUD caused a reduction in T4 while increasing TSH. Therefore, OUD may lead to the development of primary hypothyroidism, which needs to be investigated in future studies. BioMed Central 2023-11-30 /pmc/articles/PMC10688461/ /pubmed/38031024 http://dx.doi.org/10.1186/s12902-023-01467-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Pezeshki, Babak Pourmontaseri, Hossein Homayounfar, Reza Moghaddam, Maryam Talebi Dehghan, Azizallah Thyroid function and opium use disorder: a cross-sectional study on the Fasa adults cohort study (FACS), 2017 |
title | Thyroid function and opium use disorder: a cross-sectional study on the Fasa adults cohort study (FACS), 2017 |
title_full | Thyroid function and opium use disorder: a cross-sectional study on the Fasa adults cohort study (FACS), 2017 |
title_fullStr | Thyroid function and opium use disorder: a cross-sectional study on the Fasa adults cohort study (FACS), 2017 |
title_full_unstemmed | Thyroid function and opium use disorder: a cross-sectional study on the Fasa adults cohort study (FACS), 2017 |
title_short | Thyroid function and opium use disorder: a cross-sectional study on the Fasa adults cohort study (FACS), 2017 |
title_sort | thyroid function and opium use disorder: a cross-sectional study on the fasa adults cohort study (facs), 2017 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688461/ https://www.ncbi.nlm.nih.gov/pubmed/38031024 http://dx.doi.org/10.1186/s12902-023-01467-3 |
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