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Bacterial amidohydrolases and modified 5-fluorocytidine compounds: Novel enzyme-prodrug pairs
Gene-directed enzyme prodrug therapy is an emerging strategy for cancer treatment based on the delivery of a gene that encodes an enzyme that is able to convert a prodrug into a potent cytotoxin exclusively in target cancer cells. However, it is limited by the lack of suitable enzyme variants and a...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688628/ https://www.ncbi.nlm.nih.gov/pubmed/38032917 http://dx.doi.org/10.1371/journal.pone.0294696 |