Cargando…

Bacterial amidohydrolases and modified 5-fluorocytidine compounds: Novel enzyme-prodrug pairs

Gene-directed enzyme prodrug therapy is an emerging strategy for cancer treatment based on the delivery of a gene that encodes an enzyme that is able to convert a prodrug into a potent cytotoxin exclusively in target cancer cells. However, it is limited by the lack of suitable enzyme variants and a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Preitakaitė, Viktorija, Barasa, Povilas, Aučynaitė, Agota, Plakys, Gediminas, Koplūnaitė, Martyna, Zubavičiūtė, Simona, Meškys, Rolandas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688628/ https://www.ncbi.nlm.nih.gov/pubmed/38032917 http://dx.doi.org/10.1371/journal.pone.0294696

Ejemplares similares

YqfB protein from Escherichia coli: an atypical amidohydrolase active towards N(4)-acylcytosine derivatives
por: Stanislauskienė, Rūta, et al.
Publicado: (2020)

Comparative Analysis of Mesophilic YqfB-Type Amidohydrolases
por: Statkevičiūtė, Roberta, et al.
Publicado: (2022)

Discovery of Bacterial Deaminases That Convert 5-Fluoroisocytosine Into 5-Fluorouracil
por: Aučynaitė, Agota, et al.
Publicado: (2018)

Identification of a 2′-O-Methyluridine Nucleoside Hydrolase Using the Metagenomic Libraries
por: Aučynaitė, Agota, et al.
Publicado: (2018)

Characterization of Paenibacillus sp. GKG Endo-β-1, 3-Glucanase, a Member of Family 81 Glycoside Hydrolases
por: Plakys, Gediminas, et al.
Publicado: (2022)

Phoretic interactions and oscillations in active suspensions of growing Escherichia coli
por: Šimkus, Remigijus, et al.
Publicado: (2018)

Application of the uridine auxotrophic host and synthetic nucleosides for a rapid selection of hydrolases from metagenomic libraries
por: Urbelienė, Nina, et al.
Publicado: (2018)

Evolution of tRNA(Phe):imG2 methyltransferases involved in the biosynthesis of wyosine derivatives in Archaea
por: Urbonavičius, Jaunius, et al.
Publicado: (2016)

Comparative Antitumor Activity and Intestinal Toxicity of 5′‐Deoxy‐5‐fluorouridine and Its Prodrug Trimethoxybenzoyl‐5′‐deoxy‐5‐fluorocytidine
por: Ninomiya, Yasuyuki, et al.
Publicado: (1990)

Isocytosine deaminase Vcz as a novel tool for the prodrug cancer therapy
por: Kazlauskas, Arunas, et al.
Publicado: (2019)

TudS desulfidases recycle 4-thiouridine-5’-monophosphate at a catalytic [4Fe-4S] cluster
por: Fuchs, Jonathan, et al.
Publicado: (2023)

The First Step of Biodegradation of 7-Hydroxycoumarin in Pseudomonas mandelii 7HK4 Depends on an Alcohol Dehydrogenase-Type Enzyme
por: Krikštaponis, Arūnas, et al.
Publicado: (2021)

Prospecting for Unannotated Enzymes: Discovery of a 3′,5′-Nucleotide Bisphosphate Phosphatase within the Amidohydrolase Superfamily
por: Cummings, Jennifer A., et al.
Publicado: (2014)

Bioconversion of Biologically Active Indole Derivatives with Indole-3-Acetic Acid-Degrading Enzymes from Caballeronia glathei DSM50014
por: Sadauskas, Mikas, et al.
Publicado: (2020)

Generation of human ER chaperone BiP in yeast Saccharomyces cerevisiae
por: Čiplys, Evaldas, et al.
Publicado: (2014)

Allantoate amidohydrolase transcript expression is independent of drought tolerance in soybean
por: Charlson, Dirk V., et al.
Publicado: (2009)

Target selection and annotation for the structural genomics of the amidohydrolase and enolase superfamilies
por: Pieper, Ursula, et al.
Publicado: (2009)

Substrate specificity and function of acetylpolyamine amidohydrolases from Pseudomonas aeruginosa
por: Krämer, Andreas, et al.
Publicado: (2016)

Different Mechanisms of DNA Radiosensitization by 8-Bromoadenosine and 2′-Deoxy-2′-fluorocytidine Observed on DNA Origami Nanoframe Supports
por: Sala, Leo, et al.
Publicado: (2022)

Isoenzyme N-Acyl-l-Amino Acid Amidohydrolase NA Increases Ochratoxin A Degradation Efficacy of Stenotrophomonas sp. CW117 by Enhancing Amidohydrolase ADH3 Stability
por: Chen, Nan, et al.
Publicado: (2022)

Biodegradation of 7-Hydroxycoumarin in Pseudomonas mandelii 7HK4 via ipso-Hydroxylation of 3-(2,4-Dihydroxyphenyl)-propionic Acid
por: Krikštaponis, Arūnas, et al.
Publicado: (2018)

Galactaro δ-Lactone Isomerase: Lactone Isomerization by a Member of the Amidohydrolase Superfamily
por: Bouvier, Jason T., et al.
Publicado: (2014)

A Role for Allantoate Amidohydrolase (AtAAH) in the Germination of Arabidopsis thaliana Seeds
por: Yazdanpanah, Farzaneh, et al.
Publicado: (2022)

Prodrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy)
por: Denny, William A
Publicado: (2003)

A Molecular Phylogenomic Analysis of the ILR1-Like Family of IAA Amidohydrolase Genes
por: Campanella, James J., et al.
Publicado: (2003)

Characterization of Four Bifunctional Plant IAM/PAM-Amidohydrolases Capable of Contributing to Auxin Biosynthesis
por: Sánchez-Parra, Beatriz, et al.
Publicado: (2014)

N-Carbamoylputrescine Amidohydrolase of Bacteroides thetaiotaomicron, a Dominant Species of the Human Gut Microbiota
por: Shimokawa, Hiromi, et al.
Publicado: (2023)

Biosynthesis of wyosine derivatives in tRNA(Phe) of Archaea: role of a remarkable bifunctional tRNA(Phe):m(1)G/imG2 methyltransferase
por: Urbonavičius, Jaunius, et al.
Publicado: (2014)

A versatile method for the UVA-induced cross-linking of acetophenone- or benzophenone-functionalized DNA
por: Jakubovska, Jevgenija, et al.
Publicado: (2018)

Heterologous Expression and Characterization of A Novel Ochratoxin A Degrading Enzyme, N-acyl-L-amino Acid Amidohydrolase, from Alcaligenes faecalis
por: Zhang, Honghai, et al.
Publicado: (2019)

Cathepsin B-Cleavable Cyclopeptidic Chemotherapeutic Prodrugs
por: Herceg, Viktorija, et al.
Publicado: (2020)

Substrate Mediated Enzyme Prodrug Therapy
por: Fejerskov, Betina, et al.
Publicado: (2012)

Enzyme Models—From Catalysis to Prodrugs
por: Breijyeh, Zeinab, et al.
Publicado: (2021)

Chemotherapy-induced CDA expression renders resistant non-small cell lung cancer cells sensitive to 5′-deoxy-5-fluorocytidine (5′-DFCR)
por: Gao, Yanyun, et al.
Publicado: (2021)

Functionalization of α-synuclein fibrils
por: Povilonienė, Simona, et al.
Publicado: (2015)

A drought‐responsive rice amidohydrolase is the elusive plant guanine deaminase with the potential to modulate the epigenome
por: Gotarkar, Dhananjay, et al.
Publicado: (2021)

Caffeic Acid, Quercetin and 5-Fluorocytidine-Functionalized Au-Fe(3)O(4) Nanoheterodimers for X-ray-Triggered Drug Delivery in Breast Tumor Spheroids
por: Klein, Stefanie, et al.
Publicado: (2021)

Microbial cytosine deaminase is a programmable anticancer prodrug mediating enzyme: antibody, and gene directed enzyme prodrug therapy
por: El-Sayed, Ashraf S.A., et al.
Publicado: (2022)

N (4)-acyl-2′-deoxycytidine-5′-triphosphates for the enzymatic synthesis of modified DNA
por: Jakubovska, Jevgenija, et al.
Publicado: (2018)

Ureidoglycolate hydrolase, amidohydrolase, lyase: how errors in biological databases are incorporated in scientific papers and vice versa
por: Percudani, Riccardo, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_luin6bajcakrkqdr3jm4drm1bj