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Risk of cancer in acromegaly patients: An updated meta-analysis and systematic review

The incidence of cancer in acromegaly patients may be higher than that in the general population, although this has not been fully elucidated yet. This study analyzed the risk of various important types of cancer in acromegaly patients. The study was registered in INPLASY (registration number: INPLA...

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Detalles Bibliográficos
Autores principales: Xiao, Zhehao, Xiao, Pingping, Wang, Yong, Fang, Chen, Li, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688666/
https://www.ncbi.nlm.nih.gov/pubmed/38032888
http://dx.doi.org/10.1371/journal.pone.0285335
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author Xiao, Zhehao
Xiao, Pingping
Wang, Yong
Fang, Chen
Li, Yong
author_facet Xiao, Zhehao
Xiao, Pingping
Wang, Yong
Fang, Chen
Li, Yong
author_sort Xiao, Zhehao
collection PubMed
description The incidence of cancer in acromegaly patients may be higher than that in the general population, although this has not been fully elucidated yet. This study analyzed the risk of various important types of cancer in acromegaly patients. The study was registered in INPLASY (registration number: INPLASY202340037). The PubMed, Web of Science, and EMBASE databases were searched for studies based on strict inclusion and exclusion criteria, from the time of database inception up to June 30, 2022. All observational studies of acromegaly patients with cancer were included, without language restrictions. We used the Newcastle–Ottawa scale (NOS) checklist to assess the quality of evidence. A meta-analysis revealed the relationship between acromegaly and cancer using the standardized incidence rates (SIRs) and 95% confidence intervals (CIs) retrieved from the included studies. Nineteen studies were included and analyzed. The overall incidence of cancer (SIR = 1.45, 95%CI = 1.20–1.75), as well as that of thyroid (SIR = 6.96, 95%CI = 2.51–19.33), colorectal and anal (SIR = 1.95, 95%CI = 1.32–2.87), brain and central nervous system (SIR = 6.14, 95%CI = 2.73–13.84), gastric (SIR = 3.09, 95%CI = 1.47–6.50), urinary (SIR = 2.66, 95%CI = 1.88–3.76), hematological (SIR = 1.89, 95%CI = 1.17–3.06), pancreatic and small intestine (SIR = 2.59, 95%CI = 1.58–4.24), and connective tissue (SIR = 3.15, 95%CI = 1.18–8.36) cancers, was higher among patients with acromegaly than among the general population. No association between acromegaly and hepatobiliary, respiratory, reproductive, skin, breast, or prostate cancer was observed. This study demonstrated that acromegaly patients have a modestly increased chance of cancer as compared to the general population. Risk factors for cancer need to be further explored to monitor patients with acromegaly at a high risk for cancer more carefully.
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spelling pubmed-106886662023-12-01 Risk of cancer in acromegaly patients: An updated meta-analysis and systematic review Xiao, Zhehao Xiao, Pingping Wang, Yong Fang, Chen Li, Yong PLoS One Research Article The incidence of cancer in acromegaly patients may be higher than that in the general population, although this has not been fully elucidated yet. This study analyzed the risk of various important types of cancer in acromegaly patients. The study was registered in INPLASY (registration number: INPLASY202340037). The PubMed, Web of Science, and EMBASE databases were searched for studies based on strict inclusion and exclusion criteria, from the time of database inception up to June 30, 2022. All observational studies of acromegaly patients with cancer were included, without language restrictions. We used the Newcastle–Ottawa scale (NOS) checklist to assess the quality of evidence. A meta-analysis revealed the relationship between acromegaly and cancer using the standardized incidence rates (SIRs) and 95% confidence intervals (CIs) retrieved from the included studies. Nineteen studies were included and analyzed. The overall incidence of cancer (SIR = 1.45, 95%CI = 1.20–1.75), as well as that of thyroid (SIR = 6.96, 95%CI = 2.51–19.33), colorectal and anal (SIR = 1.95, 95%CI = 1.32–2.87), brain and central nervous system (SIR = 6.14, 95%CI = 2.73–13.84), gastric (SIR = 3.09, 95%CI = 1.47–6.50), urinary (SIR = 2.66, 95%CI = 1.88–3.76), hematological (SIR = 1.89, 95%CI = 1.17–3.06), pancreatic and small intestine (SIR = 2.59, 95%CI = 1.58–4.24), and connective tissue (SIR = 3.15, 95%CI = 1.18–8.36) cancers, was higher among patients with acromegaly than among the general population. No association between acromegaly and hepatobiliary, respiratory, reproductive, skin, breast, or prostate cancer was observed. This study demonstrated that acromegaly patients have a modestly increased chance of cancer as compared to the general population. Risk factors for cancer need to be further explored to monitor patients with acromegaly at a high risk for cancer more carefully. Public Library of Science 2023-11-30 /pmc/articles/PMC10688666/ /pubmed/38032888 http://dx.doi.org/10.1371/journal.pone.0285335 Text en © 2023 Xiao et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Xiao, Zhehao
Xiao, Pingping
Wang, Yong
Fang, Chen
Li, Yong
Risk of cancer in acromegaly patients: An updated meta-analysis and systematic review
title Risk of cancer in acromegaly patients: An updated meta-analysis and systematic review
title_full Risk of cancer in acromegaly patients: An updated meta-analysis and systematic review
title_fullStr Risk of cancer in acromegaly patients: An updated meta-analysis and systematic review
title_full_unstemmed Risk of cancer in acromegaly patients: An updated meta-analysis and systematic review
title_short Risk of cancer in acromegaly patients: An updated meta-analysis and systematic review
title_sort risk of cancer in acromegaly patients: an updated meta-analysis and systematic review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688666/
https://www.ncbi.nlm.nih.gov/pubmed/38032888
http://dx.doi.org/10.1371/journal.pone.0285335
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