Application of transfer learning to predict drug-induced human in vivo gene expression changes using rat in vitro and in vivo data

The liver is the primary site for the metabolism and detoxification of many compounds, including pharmaceuticals. Consequently, it is also the primary location for many adverse reactions. As the liver is not readily accessible for sampling in humans; rodent or cell line models are often used to eval...

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Detalles Bibliográficos
Autores principales: O’Donovan, Shauna D., Cavill, Rachel, Wimmenauer, Florian, Lukas, Alexander, Stumm, Tobias, Smirnov, Evgueni, Lenz, Michael, Ertaylan, Gokhan, Jennen, Danyel G. J., van Riel, Natal A. W., Driessens, Kurt, Peeters, Ralf L. M., de Kok, Theo M. C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688741/
https://www.ncbi.nlm.nih.gov/pubmed/38032940
http://dx.doi.org/10.1371/journal.pone.0292030

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