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Substrate recognition mode of a glycoside hydrolase family 42 β-galactosidase from Bifidobacterium longum subspecies infantis (BiBga42A) revealed by crystallographic and mutational analyses

Aim: Bifidobacterium longum subsp. infantis uses a glycoside hydrolase (GH) family 42 β-galactosidase (BiBga42A) for hydrolyzing lacto-N-tetraose (LNT), which is the most abundant core structure of human milk oligosaccharides (HMOs). As such, BiBga42A represents one of the pivotal enzymes underpinni...

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Detalles Bibliográficos
Autores principales: Gotoh, Aina, Hidaka, Masafumi, Sakurama, Haruko, Nishimoto, Mamoru, Kitaoka, Motomitsu, Sakanaka, Mikiyasu, Fushinobu, Shinya, Katayama, Takane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OAE Publishing Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688820/
https://www.ncbi.nlm.nih.gov/pubmed/38046823
http://dx.doi.org/10.20517/mrr.2023.14