Cargando…

National and subnational burden of leukemia and its risk factors, 1990–2019: Results from the Global Burden of Disease study 2019

BACKGROUND: Hematologic malignancies have a great essential role in cancer global burden. Leukemia which two major subtypes based on the onset, is one of the common subtypes of this malignancy. METHOD: For the GBD 2019 study, cancer registry data and vital registration system were used to estimate l...

Descripción completa

Detalles Bibliográficos
Autores principales: Poopak, Amirhossein, Saeedi Moghaddam, Sahar, Esfahani, Zahra, Keykhaei, Mohammad, Rezaei, Negar, Rezaei, Nazila, Rashidi, Mohammad-Mahdi, Ahmadi, Naser, Abbasi-Kangevari, Mohsen, Malekpour, Mohammad-Reza, Ghamari, Seyyed-Hadi, Djalalinia, Shirin, Tavangar, Seyed Mohammad, Larijani, Bagher, Kompani, Farzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688854/
https://www.ncbi.nlm.nih.gov/pubmed/38033110
http://dx.doi.org/10.1371/journal.pone.0287917
_version_ 1785152252859645952
author Poopak, Amirhossein
Saeedi Moghaddam, Sahar
Esfahani, Zahra
Keykhaei, Mohammad
Rezaei, Negar
Rezaei, Nazila
Rashidi, Mohammad-Mahdi
Ahmadi, Naser
Abbasi-Kangevari, Mohsen
Malekpour, Mohammad-Reza
Ghamari, Seyyed-Hadi
Djalalinia, Shirin
Tavangar, Seyed Mohammad
Larijani, Bagher
Kompani, Farzad
author_facet Poopak, Amirhossein
Saeedi Moghaddam, Sahar
Esfahani, Zahra
Keykhaei, Mohammad
Rezaei, Negar
Rezaei, Nazila
Rashidi, Mohammad-Mahdi
Ahmadi, Naser
Abbasi-Kangevari, Mohsen
Malekpour, Mohammad-Reza
Ghamari, Seyyed-Hadi
Djalalinia, Shirin
Tavangar, Seyed Mohammad
Larijani, Bagher
Kompani, Farzad
author_sort Poopak, Amirhossein
collection PubMed
description BACKGROUND: Hematologic malignancies have a great essential role in cancer global burden. Leukemia which two major subtypes based on the onset, is one of the common subtypes of this malignancy. METHOD: For the GBD 2019 study, cancer registry data and vital registration system were used to estimate leukemia mortality. The Meta-Regression-Bayesian Regularized Trimmed (MR-BRT), Cause of Death Ensemble model (CODEm) and Spatiotemporal Gaussian Process Regression (ST-GPR) were used to model our data and estimate each quantity of interest. Mortality to incidence ratios (MIR) were used to generate incidence and survival from mortality rate. Prevalence and survival were used to generate years lived with disability (YLDs). Age-specific mortality and life expectancy at the same age were used to estimate years of life lost (YLLs). The sum of YLLs and YLDs generates DALYs. RESULTS: The total national incidence of leukemia increased from 6092 (UI 95%: 3803–8507) in 1990 to 6767 (4646–7890) new cases in 2019. However, leukemia age-standardized incidence ratio(ASIR) decreased from 11.6 (8–14.8) to 8.9 (6.2–10.3) new cases per 100,000 in this exact period. At the national level, deaths from leukemia increased 1.5-fold between 1990 and 2019, from 3287 (2284–4201) to 4424 (3137–5030), whereas the age-standardized death rate(ASDR) decreased from 8.3 (6.1–9.8) in 1990 to 6 (4.3–6.8) per 100,000 in 2019. In the study period, total leukemia DALYs decreased 12.2% and reached 162850 (110681–188806), in 2019. The age-standardized DALYs decreased 36.7% from 324.3 (224.8–413.4) in 1990 to 205.3 (140.3–237.8) in 2019. ASDR, DALYs, YLLs, and YLDs rate to high BMI was increasing while smoking and occupational exposure to benzene and formaldehyde were decreasing in the study period. CONCLUSION: This study provided a better understanding of leukemia burden and to reduce controversies of leukemia across Iran. The leukemia status alteration of the country, is trackable.
format Online
Article
Text
id pubmed-10688854
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-106888542023-12-01 National and subnational burden of leukemia and its risk factors, 1990–2019: Results from the Global Burden of Disease study 2019 Poopak, Amirhossein Saeedi Moghaddam, Sahar Esfahani, Zahra Keykhaei, Mohammad Rezaei, Negar Rezaei, Nazila Rashidi, Mohammad-Mahdi Ahmadi, Naser Abbasi-Kangevari, Mohsen Malekpour, Mohammad-Reza Ghamari, Seyyed-Hadi Djalalinia, Shirin Tavangar, Seyed Mohammad Larijani, Bagher Kompani, Farzad PLoS One Research Article BACKGROUND: Hematologic malignancies have a great essential role in cancer global burden. Leukemia which two major subtypes based on the onset, is one of the common subtypes of this malignancy. METHOD: For the GBD 2019 study, cancer registry data and vital registration system were used to estimate leukemia mortality. The Meta-Regression-Bayesian Regularized Trimmed (MR-BRT), Cause of Death Ensemble model (CODEm) and Spatiotemporal Gaussian Process Regression (ST-GPR) were used to model our data and estimate each quantity of interest. Mortality to incidence ratios (MIR) were used to generate incidence and survival from mortality rate. Prevalence and survival were used to generate years lived with disability (YLDs). Age-specific mortality and life expectancy at the same age were used to estimate years of life lost (YLLs). The sum of YLLs and YLDs generates DALYs. RESULTS: The total national incidence of leukemia increased from 6092 (UI 95%: 3803–8507) in 1990 to 6767 (4646–7890) new cases in 2019. However, leukemia age-standardized incidence ratio(ASIR) decreased from 11.6 (8–14.8) to 8.9 (6.2–10.3) new cases per 100,000 in this exact period. At the national level, deaths from leukemia increased 1.5-fold between 1990 and 2019, from 3287 (2284–4201) to 4424 (3137–5030), whereas the age-standardized death rate(ASDR) decreased from 8.3 (6.1–9.8) in 1990 to 6 (4.3–6.8) per 100,000 in 2019. In the study period, total leukemia DALYs decreased 12.2% and reached 162850 (110681–188806), in 2019. The age-standardized DALYs decreased 36.7% from 324.3 (224.8–413.4) in 1990 to 205.3 (140.3–237.8) in 2019. ASDR, DALYs, YLLs, and YLDs rate to high BMI was increasing while smoking and occupational exposure to benzene and formaldehyde were decreasing in the study period. CONCLUSION: This study provided a better understanding of leukemia burden and to reduce controversies of leukemia across Iran. The leukemia status alteration of the country, is trackable. Public Library of Science 2023-11-30 /pmc/articles/PMC10688854/ /pubmed/38033110 http://dx.doi.org/10.1371/journal.pone.0287917 Text en © 2023 Poopak et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Poopak, Amirhossein
Saeedi Moghaddam, Sahar
Esfahani, Zahra
Keykhaei, Mohammad
Rezaei, Negar
Rezaei, Nazila
Rashidi, Mohammad-Mahdi
Ahmadi, Naser
Abbasi-Kangevari, Mohsen
Malekpour, Mohammad-Reza
Ghamari, Seyyed-Hadi
Djalalinia, Shirin
Tavangar, Seyed Mohammad
Larijani, Bagher
Kompani, Farzad
National and subnational burden of leukemia and its risk factors, 1990–2019: Results from the Global Burden of Disease study 2019
title National and subnational burden of leukemia and its risk factors, 1990–2019: Results from the Global Burden of Disease study 2019
title_full National and subnational burden of leukemia and its risk factors, 1990–2019: Results from the Global Burden of Disease study 2019
title_fullStr National and subnational burden of leukemia and its risk factors, 1990–2019: Results from the Global Burden of Disease study 2019
title_full_unstemmed National and subnational burden of leukemia and its risk factors, 1990–2019: Results from the Global Burden of Disease study 2019
title_short National and subnational burden of leukemia and its risk factors, 1990–2019: Results from the Global Burden of Disease study 2019
title_sort national and subnational burden of leukemia and its risk factors, 1990–2019: results from the global burden of disease study 2019
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688854/
https://www.ncbi.nlm.nih.gov/pubmed/38033110
http://dx.doi.org/10.1371/journal.pone.0287917
work_keys_str_mv AT poopakamirhossein nationalandsubnationalburdenofleukemiaanditsriskfactors19902019resultsfromtheglobalburdenofdiseasestudy2019
AT saeedimoghaddamsahar nationalandsubnationalburdenofleukemiaanditsriskfactors19902019resultsfromtheglobalburdenofdiseasestudy2019
AT esfahanizahra nationalandsubnationalburdenofleukemiaanditsriskfactors19902019resultsfromtheglobalburdenofdiseasestudy2019
AT keykhaeimohammad nationalandsubnationalburdenofleukemiaanditsriskfactors19902019resultsfromtheglobalburdenofdiseasestudy2019
AT rezaeinegar nationalandsubnationalburdenofleukemiaanditsriskfactors19902019resultsfromtheglobalburdenofdiseasestudy2019
AT rezaeinazila nationalandsubnationalburdenofleukemiaanditsriskfactors19902019resultsfromtheglobalburdenofdiseasestudy2019
AT rashidimohammadmahdi nationalandsubnationalburdenofleukemiaanditsriskfactors19902019resultsfromtheglobalburdenofdiseasestudy2019
AT ahmadinaser nationalandsubnationalburdenofleukemiaanditsriskfactors19902019resultsfromtheglobalburdenofdiseasestudy2019
AT abbasikangevarimohsen nationalandsubnationalburdenofleukemiaanditsriskfactors19902019resultsfromtheglobalburdenofdiseasestudy2019
AT malekpourmohammadreza nationalandsubnationalburdenofleukemiaanditsriskfactors19902019resultsfromtheglobalburdenofdiseasestudy2019
AT ghamariseyyedhadi nationalandsubnationalburdenofleukemiaanditsriskfactors19902019resultsfromtheglobalburdenofdiseasestudy2019
AT djalaliniashirin nationalandsubnationalburdenofleukemiaanditsriskfactors19902019resultsfromtheglobalburdenofdiseasestudy2019
AT tavangarseyedmohammad nationalandsubnationalburdenofleukemiaanditsriskfactors19902019resultsfromtheglobalburdenofdiseasestudy2019
AT larijanibagher nationalandsubnationalburdenofleukemiaanditsriskfactors19902019resultsfromtheglobalburdenofdiseasestudy2019
AT kompanifarzad nationalandsubnationalburdenofleukemiaanditsriskfactors19902019resultsfromtheglobalburdenofdiseasestudy2019