Hypertriglyceridemia in Apoa5(–/–) mice results from reduced amounts of lipoprotein lipase in the capillary lumen

Why apolipoprotein AV (APOA5) deficiency causes hypertriglyceridemia has remained unclear, but we have suspected that the underlying cause is reduced amounts of lipoprotein lipase (LPL) in capillaries. By routine immunohistochemistry, we observed reduced LPL staining of heart and brown adipose tissu...

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Detalles Bibliográficos
Autores principales: Yang, Ye, Beigneux, Anne P., Song, Wenxin, Nguyen, Le Phuong, Jung, Hyesoo, Tu, Yiping, Weston, Thomas A., Tran, Caitlyn M., Xie, Katherine, Yu, Rachel G., Tran, Anh P., Miyashita, Kazuya, Nakajima, Katsuyuki, Murakami, Masami, Chen, Yan Q., Zhen, Eugene Y., Kim, Joonyoung R., Kim, Paul H., Birrane, Gabriel, Tontonoz, Peter, Ploug, Michael, Konrad, Robert J., Fong, Loren G., Young, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688983/
https://www.ncbi.nlm.nih.gov/pubmed/37824203
http://dx.doi.org/10.1172/JCI172600

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