USP47 inhibits m(6)A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis

The functional integrity of Tregs is interwoven with cellular metabolism; however, the mechanisms governing Treg metabolic programs remain elusive. Here, we identified that the deubiquitinase USP47 inhibited c-Myc translation mediated by the RNA N(6)-methyladenosine (m(6)A) reader YTHDF1 to maintain...

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Detalles Bibliográficos
Autores principales: Wang, Aiting, Huang, Haiyan, Shi, Jian-Hong, Yu, Xiaoyan, Ding, Rui, Zhang, Yuerong, Han, Qiaoqiao, Ni, Zhi-Yu, Li, Xia, Zhao, Ren, Zou, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688989/
https://www.ncbi.nlm.nih.gov/pubmed/37788092
http://dx.doi.org/10.1172/JCI169365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688989/
https://www.ncbi.nlm.nih.gov/pubmed/37788092
http://dx.doi.org/10.1172/JCI169365

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