Activation of the pentose phosphate pathway in macrophages is crucial for granuloma formation in sarcoidosis

Sarcoidosis is a disease of unknown etiology in which granulomas form throughout the body and is typically treated with glucocorticoids, but there are no approved steroid-sparing alternatives. Here, we investigated the mechanism of granuloma formation using single-cell RNA-Seq in sarcoidosis patient...

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Detalles Bibliográficos
Autores principales: Nakamizo, Satoshi, Sugiura, Yuki, Ishida, Yoshihiro, Ueki, Yoko, Yonekura, Satoru, Tanizaki, Hideaki, Date, Hiroshi, Yoshizawa, Akihiko, Murata, Teruasa, Minatoya, Kenji, Katagiri, Mikako, Nomura, Seitaro, Komuro, Issei, Ogawa, Seishi, Nakajima, Saeko, Kambe, Naotomo, Egawa, Gyohei, Kabashima, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688990/
https://www.ncbi.nlm.nih.gov/pubmed/38038136
http://dx.doi.org/10.1172/JCI171088

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