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Is the vitamin D status of patients with COVID-19 associated with reduced mortality? A systematic review and meta-analysis
To conduct a systematic review and meta-analysis of studies assessing the association between serum vitamin D status and mortality in patients with COVID- 19. We searched PubMed and Embase for studies addressing the association of serum vitamin D levels and COVID-19 mortality published until April 2...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Endocrinologia e Metabologia
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689034/ https://www.ncbi.nlm.nih.gov/pubmed/36913680 http://dx.doi.org/10.20945/2359-3997000000588 |
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author | Bignardi, Paulo R. Castello, Paula de Andrade Aquino, Bruno de Matos Delfino, Vinicius Daher Alvares |
author_facet | Bignardi, Paulo R. Castello, Paula de Andrade Aquino, Bruno de Matos Delfino, Vinicius Daher Alvares |
author_sort | Bignardi, Paulo R. |
collection | PubMed |
description | To conduct a systematic review and meta-analysis of studies assessing the association between serum vitamin D status and mortality in patients with COVID- 19. We searched PubMed and Embase for studies addressing the association of serum vitamin D levels and COVID-19 mortality published until April 24, 2022. Risk ratios (RRs) and 95% confidence interval (CIs) were pooled using fixed or random effects models. The risk of bias was assessed using the Newcastle-Ottawa Scale. The meta-analysis included 21 studies that measured serum vitamin D levels close to the date of admission, of which 2 were case- control and 19 were cohort studies. Vitamin D deficiency was associated with COVID-19 mortality in the overall analysis but not when the analysis was adjusted to vitamin D cutoff levels < 10 or < 12 ng/mL (RR 1.60, 95% CI 0.93-2.27, I2 60.2%). Similarly, analyses including only studies that adjusted measures of effect for confounders showed no association between vitamin D status and death. However, when the analysis included studies without adjustments for confounding factors, the RR was 1.51 (95% CI 1.28-1.74, I2 0.0%), suggesting that confounders may have led to many observational studies incorrectly estimating the association between vitamin D status and mortality in patients with COVID-19. Deficient vitamin D levels were not associated with increased mortality rate in patients with COVID-19 when the analysis included studies with adjustments for confounders. Randomized clinical trials are needed to assess this association. |
format | Online Article Text |
id | pubmed-10689034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Sociedade Brasileira de Endocrinologia e Metabologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-106890342023-12-01 Is the vitamin D status of patients with COVID-19 associated with reduced mortality? A systematic review and meta-analysis Bignardi, Paulo R. Castello, Paula de Andrade Aquino, Bruno de Matos Delfino, Vinicius Daher Alvares Arch Endocrinol Metab Review To conduct a systematic review and meta-analysis of studies assessing the association between serum vitamin D status and mortality in patients with COVID- 19. We searched PubMed and Embase for studies addressing the association of serum vitamin D levels and COVID-19 mortality published until April 24, 2022. Risk ratios (RRs) and 95% confidence interval (CIs) were pooled using fixed or random effects models. The risk of bias was assessed using the Newcastle-Ottawa Scale. The meta-analysis included 21 studies that measured serum vitamin D levels close to the date of admission, of which 2 were case- control and 19 were cohort studies. Vitamin D deficiency was associated with COVID-19 mortality in the overall analysis but not when the analysis was adjusted to vitamin D cutoff levels < 10 or < 12 ng/mL (RR 1.60, 95% CI 0.93-2.27, I2 60.2%). Similarly, analyses including only studies that adjusted measures of effect for confounders showed no association between vitamin D status and death. However, when the analysis included studies without adjustments for confounding factors, the RR was 1.51 (95% CI 1.28-1.74, I2 0.0%), suggesting that confounders may have led to many observational studies incorrectly estimating the association between vitamin D status and mortality in patients with COVID-19. Deficient vitamin D levels were not associated with increased mortality rate in patients with COVID-19 when the analysis included studies with adjustments for confounders. Randomized clinical trials are needed to assess this association. Sociedade Brasileira de Endocrinologia e Metabologia 2023-01-31 /pmc/articles/PMC10689034/ /pubmed/36913680 http://dx.doi.org/10.20945/2359-3997000000588 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Bignardi, Paulo R. Castello, Paula de Andrade Aquino, Bruno de Matos Delfino, Vinicius Daher Alvares Is the vitamin D status of patients with COVID-19 associated with reduced mortality? A systematic review and meta-analysis |
title | Is the vitamin D status of patients with COVID-19 associated with reduced mortality? A systematic review and meta-analysis |
title_full | Is the vitamin D status of patients with COVID-19 associated with reduced mortality? A systematic review and meta-analysis |
title_fullStr | Is the vitamin D status of patients with COVID-19 associated with reduced mortality? A systematic review and meta-analysis |
title_full_unstemmed | Is the vitamin D status of patients with COVID-19 associated with reduced mortality? A systematic review and meta-analysis |
title_short | Is the vitamin D status of patients with COVID-19 associated with reduced mortality? A systematic review and meta-analysis |
title_sort | is the vitamin d status of patients with covid-19 associated with reduced mortality? a systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689034/ https://www.ncbi.nlm.nih.gov/pubmed/36913680 http://dx.doi.org/10.20945/2359-3997000000588 |
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