Cargando…
A New Behavioral Paradigm for Frustrative Nonreward in Juvenile Mice
BACKGROUND: Irritability, defined as proneness to anger, can reach a pathological extent. It is a defining symptom of disruptive mood dysregulation disorder and one of the most common reasons youths present for psychiatric evaluation and care. Aberrant responses to frustrative nonreward (FNR), the r...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689275/ https://www.ncbi.nlm.nih.gov/pubmed/38045768 http://dx.doi.org/10.1016/j.bpsgos.2023.09.007 |
_version_ | 1785152337491263488 |
---|---|
author | Naik, Aijaz Ahmad Ma, Xiaoyu Munyeshyaka, Maxime Leibenluft, Ellen Li, Zheng |
author_facet | Naik, Aijaz Ahmad Ma, Xiaoyu Munyeshyaka, Maxime Leibenluft, Ellen Li, Zheng |
author_sort | Naik, Aijaz Ahmad |
collection | PubMed |
description | BACKGROUND: Irritability, defined as proneness to anger, can reach a pathological extent. It is a defining symptom of disruptive mood dysregulation disorder and one of the most common reasons youths present for psychiatric evaluation and care. Aberrant responses to frustrative nonreward (FNR), the response to omission of expected reward, are central to the pathophysiology of irritability. FNR is a translational construct to study irritability across species. The development of preclinical FNR models would advance mechanistic studies of the important and relatively understudied clinical phenomenon of irritability. METHODS: We used FNR as a conceptual framework to develop a novel mouse behavioral paradigm named alternate poking reward omission. Juvenile mice were exposed to alternate poking reward omission and then examined with a battery of behavioral tests to determine the behavioral effect of FNR. RESULTS: FNR increased locomotion and aggression regardless of sex. These behavioral changes elicited by FNR resemble the symptoms observed in youth with severe irritability. FNR had no effect on anxiety-like, depression-like, or nonaggressive social behaviors. CONCLUSIONS: Our alternate poking reward omission paradigm effectively elevated aggression and locomotion in juvenile mice. These frustration effects are directly related to behavioral symptoms of youth with severe irritability. Our novel behavioral paradigm lays the groundwork for further mechanistic studies of frustration and irritability in rodents. |
format | Online Article Text |
id | pubmed-10689275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106892752023-12-02 A New Behavioral Paradigm for Frustrative Nonreward in Juvenile Mice Naik, Aijaz Ahmad Ma, Xiaoyu Munyeshyaka, Maxime Leibenluft, Ellen Li, Zheng Biol Psychiatry Glob Open Sci Archival Report BACKGROUND: Irritability, defined as proneness to anger, can reach a pathological extent. It is a defining symptom of disruptive mood dysregulation disorder and one of the most common reasons youths present for psychiatric evaluation and care. Aberrant responses to frustrative nonreward (FNR), the response to omission of expected reward, are central to the pathophysiology of irritability. FNR is a translational construct to study irritability across species. The development of preclinical FNR models would advance mechanistic studies of the important and relatively understudied clinical phenomenon of irritability. METHODS: We used FNR as a conceptual framework to develop a novel mouse behavioral paradigm named alternate poking reward omission. Juvenile mice were exposed to alternate poking reward omission and then examined with a battery of behavioral tests to determine the behavioral effect of FNR. RESULTS: FNR increased locomotion and aggression regardless of sex. These behavioral changes elicited by FNR resemble the symptoms observed in youth with severe irritability. FNR had no effect on anxiety-like, depression-like, or nonaggressive social behaviors. CONCLUSIONS: Our alternate poking reward omission paradigm effectively elevated aggression and locomotion in juvenile mice. These frustration effects are directly related to behavioral symptoms of youth with severe irritability. Our novel behavioral paradigm lays the groundwork for further mechanistic studies of frustration and irritability in rodents. Elsevier 2023-11-17 /pmc/articles/PMC10689275/ /pubmed/38045768 http://dx.doi.org/10.1016/j.bpsgos.2023.09.007 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Archival Report Naik, Aijaz Ahmad Ma, Xiaoyu Munyeshyaka, Maxime Leibenluft, Ellen Li, Zheng A New Behavioral Paradigm for Frustrative Nonreward in Juvenile Mice |
title | A New Behavioral Paradigm for Frustrative Nonreward in Juvenile Mice |
title_full | A New Behavioral Paradigm for Frustrative Nonreward in Juvenile Mice |
title_fullStr | A New Behavioral Paradigm for Frustrative Nonreward in Juvenile Mice |
title_full_unstemmed | A New Behavioral Paradigm for Frustrative Nonreward in Juvenile Mice |
title_short | A New Behavioral Paradigm for Frustrative Nonreward in Juvenile Mice |
title_sort | new behavioral paradigm for frustrative nonreward in juvenile mice |
topic | Archival Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689275/ https://www.ncbi.nlm.nih.gov/pubmed/38045768 http://dx.doi.org/10.1016/j.bpsgos.2023.09.007 |
work_keys_str_mv | AT naikaijazahmad anewbehavioralparadigmforfrustrativenonrewardinjuvenilemice AT maxiaoyu anewbehavioralparadigmforfrustrativenonrewardinjuvenilemice AT munyeshyakamaxime anewbehavioralparadigmforfrustrativenonrewardinjuvenilemice AT leibenluftellen anewbehavioralparadigmforfrustrativenonrewardinjuvenilemice AT lizheng anewbehavioralparadigmforfrustrativenonrewardinjuvenilemice AT naikaijazahmad newbehavioralparadigmforfrustrativenonrewardinjuvenilemice AT maxiaoyu newbehavioralparadigmforfrustrativenonrewardinjuvenilemice AT munyeshyakamaxime newbehavioralparadigmforfrustrativenonrewardinjuvenilemice AT leibenluftellen newbehavioralparadigmforfrustrativenonrewardinjuvenilemice AT lizheng newbehavioralparadigmforfrustrativenonrewardinjuvenilemice |