Methylglyoxal from gut microbes boosts radiosensitivity and radioimmunotherapy in rectal cancer by triggering endoplasmic reticulum stress and cGAS-STING activation

BACKGROUND: Preoperative radiation therapy (preRT) is a fundamental aspect of neoadjuvant treatment for rectal cancer (RC), but the response to this treatment remains unsatisfactory. The combination of radiation therapy (RT) and immunotherapy (iRT) presents a promising approach to cancer treatment,...

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Detalles Bibliográficos
Autores principales: Zhou, Han, Wang, Lei, Lin, Zhiwen, Jiang, Chenwei, Chen, Xingte, Wang, Kai, Liu, Libin, Shao, Lingdong, Pan, Jianji, Li, Jinluan, Zhang, Da, Wu, Junxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689421/
https://www.ncbi.nlm.nih.gov/pubmed/38035726
http://dx.doi.org/10.1136/jitc-2023-007840

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