RNA helicase DDX5 modulates sorafenib sensitivity in hepatocellular carcinoma via the Wnt/β-catenin–ferroptosis axis

Reduced expression of the RNA helicase DDX5 associated with increased hepatocellular carcinoma (HCC) tumor grade and poor patient survival following treatment with sorafenib. While immunotherapy is the first-line treatment for HCC, sorafenib and other multi-tyrosine kinase inhibitors (mTKIs) are wid...

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Detalles Bibliográficos
Autores principales: Li, Zhili, Caron de Fromentel, Claude, Kim, Woojun, Wang, Wen-Hung, Sun, Jiazeng, Yan, Bingyu, Utturkar, Sagar, Lanman, Nadia Atallah, Elzey, Bennett D., Yeo, Yoon, Zhang, Hao, Kazemian, Majid, Levrero, Massimo, Andrisani, Ourania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689482/
https://www.ncbi.nlm.nih.gov/pubmed/38036507
http://dx.doi.org/10.1038/s41419-023-06302-0

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