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Weight loss from diagnosis of Crohn’s disease to one year post-diagnosis results in earlier surgery
Malnutrition might play a key role in the prognosis of patients with Crohn’s disease (CD). The aim of this study was to explore the impact of weight loss from diagnosis of CD to one-year post-diagnosis on disease prognosis in terms of surgery. Patients who were diagnosed with CD at Samsung Medical C...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689484/ https://www.ncbi.nlm.nih.gov/pubmed/38036713 http://dx.doi.org/10.1038/s41598-023-48474-x |
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author | Kim, Minjee Cho, Minsung Hong, Sungjun Song, Joo Hye Kim, Eun Ran Hong, Sung Noh Chang, Dong Kyung Kim, Young-Ho Kim, Ji Eun |
author_facet | Kim, Minjee Cho, Minsung Hong, Sungjun Song, Joo Hye Kim, Eun Ran Hong, Sung Noh Chang, Dong Kyung Kim, Young-Ho Kim, Ji Eun |
author_sort | Kim, Minjee |
collection | PubMed |
description | Malnutrition might play a key role in the prognosis of patients with Crohn’s disease (CD). The aim of this study was to explore the impact of weight loss from diagnosis of CD to one-year post-diagnosis on disease prognosis in terms of surgery. Patients who were diagnosed with CD at Samsung Medical Center between 1995 to 2020 were included in this study. The study defined the “group with weight loss” as patients with weight loss in one year after diagnosis and the “group without body weight loss” as patients without weight loss in one year after diagnosis. Their data such as demographics, laboratory findings, and medical interventions were collected retrospectively. The primary outcome was confirmation of the difference in the incidence of surgery associated with CD between the group with weight loss and the group without body weight loss. We further analyzed factors associated with surgery outcomes. A total of 165 patients were analyzed in this study. Forty-one patients (24.8%) had body weight loss whereas 124 patients (75.2%) had no body weight loss. Body change at one year showed no significant association with direct surgical incidence. However, the patients with weight loss tended to undergo surgery earlier than patients without body weight loss. Among factors associated with outcomes of Crohn’s surgery, the albumin was the only significant factor. Patients with weight loss had no statistically significant increase in the risk of surgery than patients without weight loss, although they tended to undergo surgery earlier than patients without body weight loss. A prospective study is needed to determine serial body weight changes during follow-up for patients with CD. |
format | Online Article Text |
id | pubmed-10689484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-106894842023-12-02 Weight loss from diagnosis of Crohn’s disease to one year post-diagnosis results in earlier surgery Kim, Minjee Cho, Minsung Hong, Sungjun Song, Joo Hye Kim, Eun Ran Hong, Sung Noh Chang, Dong Kyung Kim, Young-Ho Kim, Ji Eun Sci Rep Article Malnutrition might play a key role in the prognosis of patients with Crohn’s disease (CD). The aim of this study was to explore the impact of weight loss from diagnosis of CD to one-year post-diagnosis on disease prognosis in terms of surgery. Patients who were diagnosed with CD at Samsung Medical Center between 1995 to 2020 were included in this study. The study defined the “group with weight loss” as patients with weight loss in one year after diagnosis and the “group without body weight loss” as patients without weight loss in one year after diagnosis. Their data such as demographics, laboratory findings, and medical interventions were collected retrospectively. The primary outcome was confirmation of the difference in the incidence of surgery associated with CD between the group with weight loss and the group without body weight loss. We further analyzed factors associated with surgery outcomes. A total of 165 patients were analyzed in this study. Forty-one patients (24.8%) had body weight loss whereas 124 patients (75.2%) had no body weight loss. Body change at one year showed no significant association with direct surgical incidence. However, the patients with weight loss tended to undergo surgery earlier than patients without body weight loss. Among factors associated with outcomes of Crohn’s surgery, the albumin was the only significant factor. Patients with weight loss had no statistically significant increase in the risk of surgery than patients without weight loss, although they tended to undergo surgery earlier than patients without body weight loss. A prospective study is needed to determine serial body weight changes during follow-up for patients with CD. Nature Publishing Group UK 2023-11-30 /pmc/articles/PMC10689484/ /pubmed/38036713 http://dx.doi.org/10.1038/s41598-023-48474-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kim, Minjee Cho, Minsung Hong, Sungjun Song, Joo Hye Kim, Eun Ran Hong, Sung Noh Chang, Dong Kyung Kim, Young-Ho Kim, Ji Eun Weight loss from diagnosis of Crohn’s disease to one year post-diagnosis results in earlier surgery |
title | Weight loss from diagnosis of Crohn’s disease to one year post-diagnosis results in earlier surgery |
title_full | Weight loss from diagnosis of Crohn’s disease to one year post-diagnosis results in earlier surgery |
title_fullStr | Weight loss from diagnosis of Crohn’s disease to one year post-diagnosis results in earlier surgery |
title_full_unstemmed | Weight loss from diagnosis of Crohn’s disease to one year post-diagnosis results in earlier surgery |
title_short | Weight loss from diagnosis of Crohn’s disease to one year post-diagnosis results in earlier surgery |
title_sort | weight loss from diagnosis of crohn’s disease to one year post-diagnosis results in earlier surgery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689484/ https://www.ncbi.nlm.nih.gov/pubmed/38036713 http://dx.doi.org/10.1038/s41598-023-48474-x |
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