Engineered immunogens to elicit antibodies against conserved coronavirus epitopes

Immune responses to SARS-CoV-2 primarily target the receptor binding domain of the spike protein, which continually mutates to escape acquired immunity. Other regions in the spike S2 subunit, such as the stem helix and the segment encompassing residues 815-823 adjacent to the fusion peptide, are hig...

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Detalles Bibliográficos
Autores principales: Kapingidza, A. Brenda, Marston, Daniel J., Harris, Caitlin, Wrapp, Daniel, Winters, Kaitlyn, Mielke, Dieter, Xiaozhi, Lu, Yin, Qi, Foulger, Andrew, Parks, Rob, Barr, Maggie, Newman, Amanda, Schäfer, Alexandra, Eaton, Amanda, Flores, Justine Mae, Harner, Austin, Catanzaro, Nicholas J., Mallory, Michael L., Mattocks, Melissa D., Beverly, Christopher, Rhodes, Brianna, Mansouri, Katayoun, Van Itallie, Elizabeth, Vure, Pranay, Dunn, Brooke, Keyes, Taylor, Stanfield-Oakley, Sherry, Woods, Christopher W., Petzold, Elizabeth A., Walter, Emmanuel B., Wiehe, Kevin, Edwards, Robert J., Montefiori, David C., Ferrari, Guido, Baric, Ralph, Cain, Derek W., Saunders, Kevin O., Haynes, Barton F., Azoitei, Mihai L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689493/
https://www.ncbi.nlm.nih.gov/pubmed/38036525
http://dx.doi.org/10.1038/s41467-023-43638-9

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