CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resection

Keeping replication fork stable is essential for safeguarding genome integrity; hence, its protection is highly regulated. The CTC1-STN1-TEN1 (CST) complex protects stalled forks from aberrant MRE11-mediated nascent strand DNA degradation (NSD). However, the activation mechanism for CST at forks is...

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Detalles Bibliográficos
Autores principales: Jaiswal, Rishi Kumar, Lei, Kai-Hang, Chastain, Megan, Wang, Yuan, Shiva, Olga, Li, Shan, You, Zhongsheng, Chi, Peter, Chai, Weihang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689503/
https://www.ncbi.nlm.nih.gov/pubmed/38036565
http://dx.doi.org/10.1038/s41467-023-43685-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689503/
https://www.ncbi.nlm.nih.gov/pubmed/38036565
http://dx.doi.org/10.1038/s41467-023-43685-2

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