Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes

Alkene dicarbofunctionalization is an efficient strategy and operation-economic fashion for introducing complexity in molecules. A nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes for the simultaneous construction of one C(sp(3))−C(sp(3)) bond and one C(sp(3))−C(sp(2)) bond ha...

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Autores principales: Gao, Yuxi, Gao, Lijuan, Zhu, Endiao, Yang, Yunhong, Jie, Mi, Zhang, Jiaqian, Pan, Zhiqiang, Xia, Chengfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689762/
https://www.ncbi.nlm.nih.gov/pubmed/38036527
http://dx.doi.org/10.1038/s41467-023-43748-4
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author Gao, Yuxi
Gao, Lijuan
Zhu, Endiao
Yang, Yunhong
Jie, Mi
Zhang, Jiaqian
Pan, Zhiqiang
Xia, Chengfeng
author_facet Gao, Yuxi
Gao, Lijuan
Zhu, Endiao
Yang, Yunhong
Jie, Mi
Zhang, Jiaqian
Pan, Zhiqiang
Xia, Chengfeng
author_sort Gao, Yuxi
collection PubMed
description Alkene dicarbofunctionalization is an efficient strategy and operation-economic fashion for introducing complexity in molecules. A nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes for the simultaneous construction of one C(sp(3))−C(sp(3)) bond and one C(sp(3))−C(sp(2)) bond has been developed. The mild catalytic method provided valuable indanethylamine derivatives with wide substrate scope and good functional group compatibility. An enantioselective dicarbofunctionalization was also achieved with pyridine-oxazoline as a ligand. The efficiency of metallaphotoredox dicarbofunctionalization was demonstrated for the concise synthesis of pharmaceutically active compounds.
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spelling pubmed-106897622023-12-02 Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes Gao, Yuxi Gao, Lijuan Zhu, Endiao Yang, Yunhong Jie, Mi Zhang, Jiaqian Pan, Zhiqiang Xia, Chengfeng Nat Commun Article Alkene dicarbofunctionalization is an efficient strategy and operation-economic fashion for introducing complexity in molecules. A nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes for the simultaneous construction of one C(sp(3))−C(sp(3)) bond and one C(sp(3))−C(sp(2)) bond has been developed. The mild catalytic method provided valuable indanethylamine derivatives with wide substrate scope and good functional group compatibility. An enantioselective dicarbofunctionalization was also achieved with pyridine-oxazoline as a ligand. The efficiency of metallaphotoredox dicarbofunctionalization was demonstrated for the concise synthesis of pharmaceutically active compounds. Nature Publishing Group UK 2023-11-30 /pmc/articles/PMC10689762/ /pubmed/38036527 http://dx.doi.org/10.1038/s41467-023-43748-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Gao, Yuxi
Gao, Lijuan
Zhu, Endiao
Yang, Yunhong
Jie, Mi
Zhang, Jiaqian
Pan, Zhiqiang
Xia, Chengfeng
Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes
title Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes
title_full Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes
title_fullStr Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes
title_full_unstemmed Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes
title_short Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes
title_sort nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689762/
https://www.ncbi.nlm.nih.gov/pubmed/38036527
http://dx.doi.org/10.1038/s41467-023-43748-4
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