Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s disease

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Many of the Alzheimer’s disease (AD) risk genes are specifically expressed in microglia and astrocytes, but how and when the genetic risk localizing to these cell types contributes to AD pathophysiology remains unclear. Here, we derive cell-type-specific AD polygenic risk scores (ADPRS) from two ext...

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Detalles Bibliográficos
Autores principales: Yang, Hyun-Sik, Teng, Ling, Kang, Daniel, Menon, Vilas, Ge, Tian, Finucane, Hilary K., Schultz, Aaron P., Properzi, Michael, Klein, Hans-Ulrich, Chibnik, Lori B., Schneider, Julie A., Bennett, David A., Hohman, Timothy J., Mayeux, Richard P., Johnson, Keith A., De Jager, Philip L., Sperling, Reisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689816/
https://www.ncbi.nlm.nih.gov/pubmed/38036535
http://dx.doi.org/10.1038/s41467-023-43132-2

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