Single-molecule visualization of human A(2A) adenosine receptor activation by a G protein and constitutively activating mutations

Mutations that constitutively activate G protein-coupled receptors (GPCRs), known as constitutively activating mutations (CAMs), modify cell signaling and interfere with drugs, resulting in diseases with limited treatment options. We utilize fluorescence imaging at the single-molecule level to visua...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Shushu, Pour, Niloofar Gopal, Tiruvadi-Krishnan, Sriram, Ray, Arka Prabha, Thakur, Naveen, Eddy, Matthew T., Lamichhane, Rajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689853/
https://www.ncbi.nlm.nih.gov/pubmed/38036689
http://dx.doi.org/10.1038/s42003-023-05603-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689853/
https://www.ncbi.nlm.nih.gov/pubmed/38036689
http://dx.doi.org/10.1038/s42003-023-05603-6

Ejemplares similares