Cargando…

Antibacterial and phytochemical analysis of traditional medicinal plants: An alternative therapeutic Approach to conventional antibiotics

The purpose of this study was to carry out antibacterial and phytochemical analyses on six selected medicinal plants that have been traditionally used by the local people to treat and control different diseases. The antibacterial activities of methanolic extracts of these plants were assessed using...

Descripción completa

Detalles Bibliográficos
Autores principales: Asfaw, Asaye, Lulekal, Ermias, Bekele, Tamrat, Debella, Asfaw, Meresa, Asfaw, Sisay, Bihonegn, Degu, Sileshi, Abebe, Abiy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689945/
https://www.ncbi.nlm.nih.gov/pubmed/38045177
http://dx.doi.org/10.1016/j.heliyon.2023.e22462
_version_ 1785152457647587328
author Asfaw, Asaye
Lulekal, Ermias
Bekele, Tamrat
Debella, Asfaw
Meresa, Asfaw
Sisay, Bihonegn
Degu, Sileshi
Abebe, Abiy
author_facet Asfaw, Asaye
Lulekal, Ermias
Bekele, Tamrat
Debella, Asfaw
Meresa, Asfaw
Sisay, Bihonegn
Degu, Sileshi
Abebe, Abiy
author_sort Asfaw, Asaye
collection PubMed
description The purpose of this study was to carry out antibacterial and phytochemical analyses on six selected medicinal plants that have been traditionally used by the local people to treat and control different diseases. The antibacterial activities of methanolic extracts of these plants were assessed using the Agar well diffusion and Microtiter broth dilution methods. The root extract of Andrachne aspera showed significantly (p < 0.05) highest mean zone of inhibition at concentrations of 100 mg/ml (33 ± 0.17) and 200 mg/ml (33.5 ± 0.84) against S. epidermidis. The second highest mean zone of inhibition (24.8 ± 0.41) was recorded by Dichrostachys cinerea leaf extract against S. epidermidis at 200 mg/ml concentration. The minimum inhibitory concentrations 1.0 ± 0.0 was recorded by Andrachne aspera against E. faecalis and 2.0 ± 0.0 against S. aureus by Dichrostachys cinerea. The preliminary phytochemical analysis showed that Andrachne aspera and Dichrostachys cinerea contained strong concentration of Polyphenols and Flavonoids. Therefore, these two medicinal plant species have promising potential for further detailed investigations, including safety tests, characterization and isolation of bioactive secondary metabolites for the development of alternative drugs.
format Online
Article
Text
id pubmed-10689945
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-106899452023-12-02 Antibacterial and phytochemical analysis of traditional medicinal plants: An alternative therapeutic Approach to conventional antibiotics Asfaw, Asaye Lulekal, Ermias Bekele, Tamrat Debella, Asfaw Meresa, Asfaw Sisay, Bihonegn Degu, Sileshi Abebe, Abiy Heliyon Research Article The purpose of this study was to carry out antibacterial and phytochemical analyses on six selected medicinal plants that have been traditionally used by the local people to treat and control different diseases. The antibacterial activities of methanolic extracts of these plants were assessed using the Agar well diffusion and Microtiter broth dilution methods. The root extract of Andrachne aspera showed significantly (p < 0.05) highest mean zone of inhibition at concentrations of 100 mg/ml (33 ± 0.17) and 200 mg/ml (33.5 ± 0.84) against S. epidermidis. The second highest mean zone of inhibition (24.8 ± 0.41) was recorded by Dichrostachys cinerea leaf extract against S. epidermidis at 200 mg/ml concentration. The minimum inhibitory concentrations 1.0 ± 0.0 was recorded by Andrachne aspera against E. faecalis and 2.0 ± 0.0 against S. aureus by Dichrostachys cinerea. The preliminary phytochemical analysis showed that Andrachne aspera and Dichrostachys cinerea contained strong concentration of Polyphenols and Flavonoids. Therefore, these two medicinal plant species have promising potential for further detailed investigations, including safety tests, characterization and isolation of bioactive secondary metabolites for the development of alternative drugs. Elsevier 2023-11-17 /pmc/articles/PMC10689945/ /pubmed/38045177 http://dx.doi.org/10.1016/j.heliyon.2023.e22462 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Asfaw, Asaye
Lulekal, Ermias
Bekele, Tamrat
Debella, Asfaw
Meresa, Asfaw
Sisay, Bihonegn
Degu, Sileshi
Abebe, Abiy
Antibacterial and phytochemical analysis of traditional medicinal plants: An alternative therapeutic Approach to conventional antibiotics
title Antibacterial and phytochemical analysis of traditional medicinal plants: An alternative therapeutic Approach to conventional antibiotics
title_full Antibacterial and phytochemical analysis of traditional medicinal plants: An alternative therapeutic Approach to conventional antibiotics
title_fullStr Antibacterial and phytochemical analysis of traditional medicinal plants: An alternative therapeutic Approach to conventional antibiotics
title_full_unstemmed Antibacterial and phytochemical analysis of traditional medicinal plants: An alternative therapeutic Approach to conventional antibiotics
title_short Antibacterial and phytochemical analysis of traditional medicinal plants: An alternative therapeutic Approach to conventional antibiotics
title_sort antibacterial and phytochemical analysis of traditional medicinal plants: an alternative therapeutic approach to conventional antibiotics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689945/
https://www.ncbi.nlm.nih.gov/pubmed/38045177
http://dx.doi.org/10.1016/j.heliyon.2023.e22462
work_keys_str_mv AT asfawasaye antibacterialandphytochemicalanalysisoftraditionalmedicinalplantsanalternativetherapeuticapproachtoconventionalantibiotics
AT lulekalermias antibacterialandphytochemicalanalysisoftraditionalmedicinalplantsanalternativetherapeuticapproachtoconventionalantibiotics
AT bekeletamrat antibacterialandphytochemicalanalysisoftraditionalmedicinalplantsanalternativetherapeuticapproachtoconventionalantibiotics
AT debellaasfaw antibacterialandphytochemicalanalysisoftraditionalmedicinalplantsanalternativetherapeuticapproachtoconventionalantibiotics
AT meresaasfaw antibacterialandphytochemicalanalysisoftraditionalmedicinalplantsanalternativetherapeuticapproachtoconventionalantibiotics
AT sisaybihonegn antibacterialandphytochemicalanalysisoftraditionalmedicinalplantsanalternativetherapeuticapproachtoconventionalantibiotics
AT degusileshi antibacterialandphytochemicalanalysisoftraditionalmedicinalplantsanalternativetherapeuticapproachtoconventionalantibiotics
AT abebeabiy antibacterialandphytochemicalanalysisoftraditionalmedicinalplantsanalternativetherapeuticapproachtoconventionalantibiotics