Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor

Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive soft-tissue sarcomas that arise from neural tissues and carry a poor prognosis. Previously, we found that the glutamine amidotransferase inhibitor JHU395 partially impeded tumor growth in preclinical models of MPNST. JHU395 inhib...

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Detalles Bibliográficos
Autores principales: Lemberg, Kathryn M., Ali, Eunus S., Krecmerova, Marcela, Aguilar, Joanna Marie H., Alt, Jesse, Peters, Diane E., Zhao, Liang, Wu, Ying, Nuha, Naziba, Asara, John M., Staedtke, Verena, Pratilas, Christine A., Majer, Pavel, Rais, Rana, Ben-Sahra, Issam, Slusher, Barbara S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690047/
https://www.ncbi.nlm.nih.gov/pubmed/37616542
http://dx.doi.org/10.1158/1535-7163.MCT-23-0258

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