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The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen

Salmonella enterica serovar Choleraesuis (S.Choleraesuis), a highly invasive serovar among non-typhoidal Salmonella, usually causes sepsis or extra-intestinal focal infections in humans. S.Choleraesuis infections have now become particularly difficult to treat because of the emergence of resistance...

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Autores principales: Chiu, Cheng-Hsun, Tang, Petrus, Chu, Chishih, Hu, Songnian, Bao, Qiyu, Yu, Jun, Chou, Yun-Ying, Wang, Hsin-Shih, Lee, Ying-Shiung
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069006/
https://www.ncbi.nlm.nih.gov/pubmed/15781495
http://dx.doi.org/10.1093/nar/gki297
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author Chiu, Cheng-Hsun
Tang, Petrus
Chu, Chishih
Hu, Songnian
Bao, Qiyu
Yu, Jun
Chou, Yun-Ying
Wang, Hsin-Shih
Lee, Ying-Shiung
author_facet Chiu, Cheng-Hsun
Tang, Petrus
Chu, Chishih
Hu, Songnian
Bao, Qiyu
Yu, Jun
Chou, Yun-Ying
Wang, Hsin-Shih
Lee, Ying-Shiung
author_sort Chiu, Cheng-Hsun
collection PubMed
description Salmonella enterica serovar Choleraesuis (S.Choleraesuis), a highly invasive serovar among non-typhoidal Salmonella, usually causes sepsis or extra-intestinal focal infections in humans. S.Choleraesuis infections have now become particularly difficult to treat because of the emergence of resistance to multiple antimicrobial agents. The 4.7 Mb genome sequence of a multidrug-resistant S.Choleraesuis strain SC-B67 was determined. Genome wide comparison of three sequenced Salmonella genomes revealed that more deletion events occurred in S.Choleraesuis SC-B67 and S.Typhi CT18 relative to S.Typhimurium LT2. S.Choleraesuis has 151 pseudogenes, which, among the three Salmonella genomes, include the highest percentage of pseudogenes arising from the genes involved in bacterial chemotaxis signal-transduction pathways. Mutations in these genes may increase smooth swimming of the bacteria, potentially allowing more effective interactions with and invasion of host cells to occur. A key regulatory gene of TetR/AcrR family, acrR, was inactivated through the introduction of an internal stop codon resulting in overexpression of AcrAB that appears to be associated with ciprofloxacin resistance. While lateral gene transfer providing basic functions to allow niche expansion in the host and environment is maintained during the evolution of different serovars of Salmonella, genes providing little overall selective benefit may be lost rapidly. Our findings suggest that the formation of pseudogenes may provide a simple evolutionary pathway that complements gene acquisition to enhance virulence and antimicrobial resistance in S.Choleraesuis.
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spelling pubmed-10690062005-03-21 The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen Chiu, Cheng-Hsun Tang, Petrus Chu, Chishih Hu, Songnian Bao, Qiyu Yu, Jun Chou, Yun-Ying Wang, Hsin-Shih Lee, Ying-Shiung Nucleic Acids Res Article Salmonella enterica serovar Choleraesuis (S.Choleraesuis), a highly invasive serovar among non-typhoidal Salmonella, usually causes sepsis or extra-intestinal focal infections in humans. S.Choleraesuis infections have now become particularly difficult to treat because of the emergence of resistance to multiple antimicrobial agents. The 4.7 Mb genome sequence of a multidrug-resistant S.Choleraesuis strain SC-B67 was determined. Genome wide comparison of three sequenced Salmonella genomes revealed that more deletion events occurred in S.Choleraesuis SC-B67 and S.Typhi CT18 relative to S.Typhimurium LT2. S.Choleraesuis has 151 pseudogenes, which, among the three Salmonella genomes, include the highest percentage of pseudogenes arising from the genes involved in bacterial chemotaxis signal-transduction pathways. Mutations in these genes may increase smooth swimming of the bacteria, potentially allowing more effective interactions with and invasion of host cells to occur. A key regulatory gene of TetR/AcrR family, acrR, was inactivated through the introduction of an internal stop codon resulting in overexpression of AcrAB that appears to be associated with ciprofloxacin resistance. While lateral gene transfer providing basic functions to allow niche expansion in the host and environment is maintained during the evolution of different serovars of Salmonella, genes providing little overall selective benefit may be lost rapidly. Our findings suggest that the formation of pseudogenes may provide a simple evolutionary pathway that complements gene acquisition to enhance virulence and antimicrobial resistance in S.Choleraesuis. Oxford University Press 2005 2005-03-21 /pmc/articles/PMC1069006/ /pubmed/15781495 http://dx.doi.org/10.1093/nar/gki297 Text en © The Author 2005. Published by Oxford University Press. All rights reserved
spellingShingle Article
Chiu, Cheng-Hsun
Tang, Petrus
Chu, Chishih
Hu, Songnian
Bao, Qiyu
Yu, Jun
Chou, Yun-Ying
Wang, Hsin-Shih
Lee, Ying-Shiung
The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen
title The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen
title_full The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen
title_fullStr The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen
title_full_unstemmed The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen
title_short The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen
title_sort genome sequence of salmonella enterica serovar choleraesuis, a highly invasive and resistant zoonotic pathogen
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069006/
https://www.ncbi.nlm.nih.gov/pubmed/15781495
http://dx.doi.org/10.1093/nar/gki297
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