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PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors

PURPOSE: Tumors activate protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK, also called EIF2AK3) in response to hypoxia and nutrient deprivation as a stress-mitigation strategy. Here, we tested the hypothesis that inhibiting PERK with HC-5404 enhances the antitumor efficacy of standard-...

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Detalles Bibliográficos
Autores principales:	Stokes, Michael E., Calvo, Veronica, Fujisawa, Sho, Dudgeon, Crissy, Huang, Sharon, Ballal, Nupur, Shen, Leyi, Gasparek, Jennifer, Betzenhauser, Matthew, Taylor, Simon J., Staschke, Kirk A., Rigby, Alan C., Mulvihill, Mark J., Bose, Nandita, Lightcap, Eric S., Surguladze, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Translational Cancer Mechanisms and Therapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690095/ https://www.ncbi.nlm.nih.gov/pubmed/37733811 http://dx.doi.org/10.1158/1078-0432.CCR-23-1182

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