The BRD4–NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma

NUT carcinoma (NC) is an aggressive squamous carcinoma defined by the BRD4–NUT fusion oncoprotein. Routinely effective systemic treatments are unavailable for most NC patients. The lack of an adequate animal model precludes identifying and leveraging cell-extrinsic factors therapeutically in NC. Her...

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Detalles Bibliográficos
Autores principales: Durall, R. Taylor, Huang, Julianna, Wojenski, Luke, Huang, Yeying, Gokhale, Prafulla C., Leeper, Brittaney A., Nash, Joshua O., Ballester, Pedro L., Davidson, Scott, Shlien, Adam, Sotirakis, Emmanuel, Bertaux, Fabien, Dubus, Vincent, Luo, Jia, Wu, Catherine J., Keskin, Derin B., Eagen, Kyle P., Shapiro, Geoffrey I., French, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Priority Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690098/
https://www.ncbi.nlm.nih.gov/pubmed/37819236
http://dx.doi.org/10.1158/0008-5472.CAN-23-2545

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