CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma

Multiple myeloma remains an incurable malignancy due to acquisition of intrinsic programs that drive therapy resistance. Here we report that casein kinase-1δ (CK1δ) and CK1ε are therapeutic targets in multiple myeloma that are necessary to sustain mitochondrial metabolism. Specifically, the dual CK1...

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Detalles Bibliográficos
Autores principales: Burger, Karen L., Fernandez, Mario R., Meads, Mark B., Sudalagunta, Praneeth, Oliveira, Paula S., Renatino Canevarolo, Rafael, Alugubelli, Raghunandan Reddy, Tungsevik, Alexandre, De Avila, Gabe, Silva, Maria, Graeter, Allison I., Dai, Hongyue A., Vincelette, Nicole D., Prabhu, Antony, Magaletti, Dario, Yang, Chunying, Li, Weimin, Kulkarni, Amit, Hampton, Oliver, Koomen, John M., Roush, William R., Monastyrskyi, Andrii, Berglund, Anders E., Silva, Ariosto S., Cleveland, John L., Shain, Kenneth H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Cancer Metabolism and Molecular Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690099/
https://www.ncbi.nlm.nih.gov/pubmed/37702657
http://dx.doi.org/10.1158/0008-5472.CAN-22-2350

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