A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites

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The specificity of small interfering RNA (siRNA)-mediated gene silencing is a critical consideration for the application of RNA interference (RNAi). While the discovery of potential off-target effects by siRNAs is of concern, no systematic analysis has been conducted to explore the specificity of RN...

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Detalles Bibliográficos
Autores principales: Du, Quan, Thonberg, Håkan, Wang, Jue, Wahlestedt, Claes, Liang, Zicai
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069010/
https://www.ncbi.nlm.nih.gov/pubmed/15781493
http://dx.doi.org/10.1093/nar/gki312

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