Clinical Characterization of [(18)F]T-008, a Cholesterol 24-Hydroxylase PET Ligand: Dosimetry, Kinetic Modeling, Variability, and Soticlestat Occupancy

This series of studies characterized [(18)F]T-008, a PET radiotracer for imaging cholesterol 24-hydroxylase (CH24H), in healthy volunteers (ClinicalTrials.gov identifier NCT02497235). Assessments included radiation dosimetry, kinetic modeling, test–retest variability (TRT) evaluation, and a dose occ...

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Detalles Bibliográficos
Autores principales: Constantinescu, Cristian C., Brown, Terry, Wang, Shining, Yin, Wei, Barret, Olivier, Jennings, Danna, Tauscher, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Nuclear Medicine 2023
Materias:
Clinical Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690114/
https://www.ncbi.nlm.nih.gov/pubmed/37770111
http://dx.doi.org/10.2967/jnumed.123.265912

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