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Potential of electro-sprayed purified mangiferin nanoparticles for anti-aging cosmetic applications

The fabrication of mangiferin nanoparticles using an electrospraying technique is a new and promising method for developing nanoparticles with higher efficiency and safety. This study aimed to fabricate mangiferin nanoparticles (MNPs) using cellulose acetate (CA) as a polymer at various parameters u...

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Autores principales: Chomchoei, Neungreuthai, Leelapornpisid, Pimporn, Tipduangta, Pratchaya, Sangthong, Padchanee, Papan, Phakorn, Sirithunyalug, Busaban, Samutrtai, Pawitrabhorn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690135/
https://www.ncbi.nlm.nih.gov/pubmed/38046636
http://dx.doi.org/10.1039/d3ra06308a
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author Chomchoei, Neungreuthai
Leelapornpisid, Pimporn
Tipduangta, Pratchaya
Sangthong, Padchanee
Papan, Phakorn
Sirithunyalug, Busaban
Samutrtai, Pawitrabhorn
author_facet Chomchoei, Neungreuthai
Leelapornpisid, Pimporn
Tipduangta, Pratchaya
Sangthong, Padchanee
Papan, Phakorn
Sirithunyalug, Busaban
Samutrtai, Pawitrabhorn
author_sort Chomchoei, Neungreuthai
collection PubMed
description The fabrication of mangiferin nanoparticles using an electrospraying technique is a new and promising method for developing nanoparticles with higher efficiency and safety. This study aimed to fabricate mangiferin nanoparticles (MNPs) using cellulose acetate (CA) as a polymer at various parameters using electrospraying. Commercial mangiferin (CM) was purified from 88.46 to 95.71% by a recrystallization method to improve its purity and biological activities and remove any residue. The properties of recrystallized mangiferin (RM) were characterized using DSC, FTIR, X-ray diffraction (XRD) and HPLC. Then its biological activity and proteomics were determined. Proteomics analysis of RM showed that up-regulated proteins were involved in more biological processes than CM. MNPs were fabricated by varying the electrospraying parameters including voltage, the distance between the needle-tip–collector and flow rate. Skin permeation, release and irritation were also evaluated. The results revealed that the average particle size of the MNPs ranged between 295.47 ± 5.58 and 448.87 ± 3.00 nm, and had a smooth spherical morphology in SEM images. The MNPs also showed good potential in antioxidant and anti-aging properties. The encapsulation efficiency of MNPs was determined to be 85.31%. From skin permeation studies of CM, RM, and MNPs, the mangiferin content was found in the stratum corneum and dermis skin layers. Moreover, the MNPs solution had 23.68 ± 0.27% and 11.98 ± 0.13% of mangiferin in the stratum corneum and viable epidermis and dermis, respectively. Additionally, the irritation test by HET-CAM was mild and safe. Therefore, MNPs produced by electrospraying are a promising delivery system for cosmetic/cosmeceutical applications.
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spelling pubmed-106901352023-12-02 Potential of electro-sprayed purified mangiferin nanoparticles for anti-aging cosmetic applications Chomchoei, Neungreuthai Leelapornpisid, Pimporn Tipduangta, Pratchaya Sangthong, Padchanee Papan, Phakorn Sirithunyalug, Busaban Samutrtai, Pawitrabhorn RSC Adv Chemistry The fabrication of mangiferin nanoparticles using an electrospraying technique is a new and promising method for developing nanoparticles with higher efficiency and safety. This study aimed to fabricate mangiferin nanoparticles (MNPs) using cellulose acetate (CA) as a polymer at various parameters using electrospraying. Commercial mangiferin (CM) was purified from 88.46 to 95.71% by a recrystallization method to improve its purity and biological activities and remove any residue. The properties of recrystallized mangiferin (RM) were characterized using DSC, FTIR, X-ray diffraction (XRD) and HPLC. Then its biological activity and proteomics were determined. Proteomics analysis of RM showed that up-regulated proteins were involved in more biological processes than CM. MNPs were fabricated by varying the electrospraying parameters including voltage, the distance between the needle-tip–collector and flow rate. Skin permeation, release and irritation were also evaluated. The results revealed that the average particle size of the MNPs ranged between 295.47 ± 5.58 and 448.87 ± 3.00 nm, and had a smooth spherical morphology in SEM images. The MNPs also showed good potential in antioxidant and anti-aging properties. The encapsulation efficiency of MNPs was determined to be 85.31%. From skin permeation studies of CM, RM, and MNPs, the mangiferin content was found in the stratum corneum and dermis skin layers. Moreover, the MNPs solution had 23.68 ± 0.27% and 11.98 ± 0.13% of mangiferin in the stratum corneum and viable epidermis and dermis, respectively. Additionally, the irritation test by HET-CAM was mild and safe. Therefore, MNPs produced by electrospraying are a promising delivery system for cosmetic/cosmeceutical applications. The Royal Society of Chemistry 2023-12-01 /pmc/articles/PMC10690135/ /pubmed/38046636 http://dx.doi.org/10.1039/d3ra06308a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Chomchoei, Neungreuthai
Leelapornpisid, Pimporn
Tipduangta, Pratchaya
Sangthong, Padchanee
Papan, Phakorn
Sirithunyalug, Busaban
Samutrtai, Pawitrabhorn
Potential of electro-sprayed purified mangiferin nanoparticles for anti-aging cosmetic applications
title Potential of electro-sprayed purified mangiferin nanoparticles for anti-aging cosmetic applications
title_full Potential of electro-sprayed purified mangiferin nanoparticles for anti-aging cosmetic applications
title_fullStr Potential of electro-sprayed purified mangiferin nanoparticles for anti-aging cosmetic applications
title_full_unstemmed Potential of electro-sprayed purified mangiferin nanoparticles for anti-aging cosmetic applications
title_short Potential of electro-sprayed purified mangiferin nanoparticles for anti-aging cosmetic applications
title_sort potential of electro-sprayed purified mangiferin nanoparticles for anti-aging cosmetic applications
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690135/
https://www.ncbi.nlm.nih.gov/pubmed/38046636
http://dx.doi.org/10.1039/d3ra06308a
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