Advanced Age in Humans and Mouse Models of Glioblastoma Show Decreased Survival from Extratumoral Influence

PURPOSE: Glioblastoma (GBM) is the most common aggressive primary malignant brain tumor in adults with a median age of onset of 68 to 70 years old. Although advanced age is often associated with poorer GBM patient survival, the predominant source(s) of maladaptive aging effects remains to be establi...

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Autores principales: Johnson, Margaret, Bell, April, Lauing, Kristen L., Ladomersky, Erik, Zhai, Lijie, Penco-Campillo, Manon, Shah, Yajas, Mauer, Elizabeth, Xiu, Joanne, Nicolaides, Theodore, Drumm, Michael, McCortney, Kathleen, Elemento, Olivier, Kim, Miri, Bommi, Prashant, Low, Justin T., Memon, Ruba, Wu, Jennifer, Zhao, Junfei, Mi, Xinlei, Glantz, Michael J., Sengupta, Soma, Castro, Brandyn, Yamini, Bakhtiar, Horbinski, Craig, Baker, Darren J., Walunas, Theresa L., Schiltz, Gary E., Lukas, Rimas V., Wainwright, Derek A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690140/
https://www.ncbi.nlm.nih.gov/pubmed/37725593
http://dx.doi.org/10.1158/1078-0432.CCR-23-0834

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