Epistasis regulates genetic control of cardiac hypertrophy

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The combinatorial effect of genetic variants is often assumed to be additive. Although genetic variation can clearly interact non-additively, methods to uncover epistatic relationships remain in their infancy. We develop low-signal signed iterative random forests to elucidate the complex genetic arc...

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Detalles Bibliográficos
Autores principales: Wang, Qianru, Tang, Tiffany, Youlton, Nathan, Weldy, Chad, Kenney, Ana, Ronen, Omer, Hughes, John, Chin, Elizabeth, Sutton, Shirley, Agarwal, Abhineet, Li, Xiao, Behr, Merle, Kumbier, Karl, Moravec, Christine, Tang, W. H. Wilson, Margulies, Kenneth, Cappola, Thomas, Butte, Atul, Arnaout, Rima, Brown, James, Priest, James, Parikh, Victoria, Yu, Bin, Ashley, Euan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690313/
https://www.ncbi.nlm.nih.gov/pubmed/38045390
http://dx.doi.org/10.21203/rs.3.rs-3509208/v1

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