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Epistasis regulates genetic control of cardiac hypertrophy
The combinatorial effect of genetic variants is often assumed to be additive. Although genetic variation can clearly interact non-additively, methods to uncover epistatic relationships remain in their infancy. We develop low-signal signed iterative random forests to elucidate the complex genetic arc...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Journal Experts
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690313/ https://www.ncbi.nlm.nih.gov/pubmed/38045390 http://dx.doi.org/10.21203/rs.3.rs-3509208/v1 |
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por Wang, Qianru, Tang, Tiffany M., Youlton, Nathan, Weldy, Chad S., Kenney, Ana M., Ronen, Omer, Hughes, J. Weston, Chin, Elizabeth T., Sutton, Shirley C., Agarwal, Abhineet, Li, Xiao, Behr, Merle, Kumbier, Karl, Moravec, Christine S., Tang, W. H. Wilson, Margulies, Kenneth B., Cappola, Thomas P., Butte, Atul J., Arnaout, Rima, Brown, James B., Priest, James R., Parikh, Victoria N., Yu, Bin, Ashley, Euan A.
Publicado 2023
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Publicado 2023
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Online
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