Cargando…
Progress in the clinical treatment of keloids
Keloid is a pathological scar that is higher than the skin surface following skin damage. Its lesion range often extends beyond the original damage boundary and does not naturally subside over time. Its pathogenesis is very complex, currently the main causes include fibroblast excessive proliferatio...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690427/ https://www.ncbi.nlm.nih.gov/pubmed/38046417 http://dx.doi.org/10.3389/fmed.2023.1284109 |
_version_ | 1785152524348555264 |
---|---|
author | Qi, Wenli Xiao, Xinyue Tong, Jing Guo, Nengqiang |
author_facet | Qi, Wenli Xiao, Xinyue Tong, Jing Guo, Nengqiang |
author_sort | Qi, Wenli |
collection | PubMed |
description | Keloid is a pathological scar that is higher than the skin surface following skin damage. Its lesion range often extends beyond the original damage boundary and does not naturally subside over time. Its pathogenesis is very complex, currently the main causes include fibroblast excessive proliferation, collagen and extracellular matrix (Extracellular matrix, ECM) excessive deposition, excessive angiogenesis, and so on. The traditional treatment method primarily involves surgical intervention, but it is associated with a high recurrence rate post-surgery. Consequently, many treatment methods are derived according to the different clinical characteristics of keloid. This paper will review the therapeutic progress in recent years from surgical treatment, physiotherapy, drug therapy, and biological therapy, with the goal of offering valuable insights for the clinical treatment of keloids. |
format | Online Article Text |
id | pubmed-10690427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106904272023-12-02 Progress in the clinical treatment of keloids Qi, Wenli Xiao, Xinyue Tong, Jing Guo, Nengqiang Front Med (Lausanne) Medicine Keloid is a pathological scar that is higher than the skin surface following skin damage. Its lesion range often extends beyond the original damage boundary and does not naturally subside over time. Its pathogenesis is very complex, currently the main causes include fibroblast excessive proliferation, collagen and extracellular matrix (Extracellular matrix, ECM) excessive deposition, excessive angiogenesis, and so on. The traditional treatment method primarily involves surgical intervention, but it is associated with a high recurrence rate post-surgery. Consequently, many treatment methods are derived according to the different clinical characteristics of keloid. This paper will review the therapeutic progress in recent years from surgical treatment, physiotherapy, drug therapy, and biological therapy, with the goal of offering valuable insights for the clinical treatment of keloids. Frontiers Media S.A. 2023-11-16 /pmc/articles/PMC10690427/ /pubmed/38046417 http://dx.doi.org/10.3389/fmed.2023.1284109 Text en Copyright © 2023 Qi, Xiao, Tong and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Qi, Wenli Xiao, Xinyue Tong, Jing Guo, Nengqiang Progress in the clinical treatment of keloids |
title | Progress in the clinical treatment of keloids |
title_full | Progress in the clinical treatment of keloids |
title_fullStr | Progress in the clinical treatment of keloids |
title_full_unstemmed | Progress in the clinical treatment of keloids |
title_short | Progress in the clinical treatment of keloids |
title_sort | progress in the clinical treatment of keloids |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690427/ https://www.ncbi.nlm.nih.gov/pubmed/38046417 http://dx.doi.org/10.3389/fmed.2023.1284109 |
work_keys_str_mv | AT qiwenli progressintheclinicaltreatmentofkeloids AT xiaoxinyue progressintheclinicaltreatmentofkeloids AT tongjing progressintheclinicaltreatmentofkeloids AT guonengqiang progressintheclinicaltreatmentofkeloids |