VWF–ADAMTS13 axis dysfunction in children with sickle cell disease treated with hydroxycarbamide vs blood transfusion

Previous studies have reported elevated von Willebrand factor (VWF) levels in patients with sickle cell disease (SCD) and demonstrated a key role for the VWF-ADAMTS13 axis in the pathobiology of SCD vaso-occlusion. Although blood transfusion is the gold standard for stroke prevention in SCD, the bio...

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Detalles Bibliográficos
Autores principales: Fogarty, Helen, Ahmad, Azaz, Atiq, Ferdows, Doherty, Dearbhla, Ward, Soracha, Karampini, Ellie, Rehill, Aisling, Leon, Gemma, Byrne, Ciara, Geoghegan, Rosena, Conroy, Helena, Byrne, Mary, Budde, Ulrich, Schneppenheim, Sonja, Sheehan, Ciara, Ngwenya, Noel, Baker, Ross I., Preston, Roger J. S., Tuohy, Emma, McMahon, Corrina, O’Donnell, James S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690561/
https://www.ncbi.nlm.nih.gov/pubmed/37773926
http://dx.doi.org/10.1182/bloodadvances.2023010824

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