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Complementary HLH susceptibility factors converge on CD8 T-cell hyperactivation

Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening hyperinflammatory syndromes. Familial HLH is caused by genetic impairment of granule-mediated cytotoxicity (eg, perforin deficiency). MAS is linked to excess activity of the inflammasome-activated...

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Detalles Bibliográficos
Autores principales:	Landy, Emily, Varghese, Jemy, Dang, Vinh, Szymczak-Workman, Andrea, Kane, Lawrence P., Canna, Scott W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2023
Materias:	Immunobiology and Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690564/ https://www.ncbi.nlm.nih.gov/pubmed/37738167 http://dx.doi.org/10.1182/bloodadvances.2023010502

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