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Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores

[Image: see text] Misfolded protein oligomers are of central importance in both the diagnosis and treatment of Alzheimer’s and Parkinson’s diseases. However, accurate high-throughput methods to detect and quantify oligomer populations are still needed. We present here a single-molecule approach for...

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Detalles Bibliográficos
Autores principales:	Sandler, Sarah E., Horne, Robert I., Rocchetti, Sara, Novak, Robert, Hsu, Nai-Shu, Castellana Cruz, Marta, Faidon Brotzakis, Z., Gregory, Rebecca C., Chia, Sean, Bernardes, Gonçalo J. L., Keyser, Ulrich F., Vendruscolo, Michele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690769/ https://www.ncbi.nlm.nih.gov/pubmed/37972287 http://dx.doi.org/10.1021/jacs.3c09335

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