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Larger corpus callosum volume is favorable for theory of mind development in healthy children
While previous research has demonstrated a link between the corpus callosum (CC) and theory of mind (ToM) abilities in individuals with corpus callosum agenesis (ACC), the relationship between CC volume and ToM remains unclear in healthy children. The present study examined whether CC volume influen...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690855/ https://www.ncbi.nlm.nih.gov/pubmed/37823275 http://dx.doi.org/10.1093/cercor/bhad353 |
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author | Mandl, Sophie Kienast, Patric Kollndorfer, Kathrin Kasprian, Gregor Weber, Michael Seidl, Rainer Bartha-Doering, Lisa |
author_facet | Mandl, Sophie Kienast, Patric Kollndorfer, Kathrin Kasprian, Gregor Weber, Michael Seidl, Rainer Bartha-Doering, Lisa |
author_sort | Mandl, Sophie |
collection | PubMed |
description | While previous research has demonstrated a link between the corpus callosum (CC) and theory of mind (ToM) abilities in individuals with corpus callosum agenesis (ACC), the relationship between CC volume and ToM remains unclear in healthy children. The present study examined whether CC volume influences children’s performance on ToM tasks that assess their understanding of pretense, emotion recognition, and false beliefs. Forty children aged 6–12 years underwent structural magnetic resonance imaging (MRI) and a cognitive test battery. We found that larger mid-anterior and central subsections of the CC significantly correlated with better ToM abilities. We could also demonstrate age- and sex-related effects, as the CC–ToM relationship differed between younger (6–8 years) and older (9–12 years) children, and between female and male participants. Importantly, the older children drove the association between the CC mid-anterior and central subsection volumes and ToM abilities. This study is the first to demonstrate that CC size is associated with ToM abilities in healthy children, underlining the idea that the CC plays a vital role in their socio-cognitive development. CC subsection volumes may thus not only serve as a measure of heterogeneity in neurodevelopmental populations known to exhibit socio-cognitive deficits, but also in typically developing children. |
format | Online Article Text |
id | pubmed-10690855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-106908552023-12-02 Larger corpus callosum volume is favorable for theory of mind development in healthy children Mandl, Sophie Kienast, Patric Kollndorfer, Kathrin Kasprian, Gregor Weber, Michael Seidl, Rainer Bartha-Doering, Lisa Cereb Cortex Original Article While previous research has demonstrated a link between the corpus callosum (CC) and theory of mind (ToM) abilities in individuals with corpus callosum agenesis (ACC), the relationship between CC volume and ToM remains unclear in healthy children. The present study examined whether CC volume influences children’s performance on ToM tasks that assess their understanding of pretense, emotion recognition, and false beliefs. Forty children aged 6–12 years underwent structural magnetic resonance imaging (MRI) and a cognitive test battery. We found that larger mid-anterior and central subsections of the CC significantly correlated with better ToM abilities. We could also demonstrate age- and sex-related effects, as the CC–ToM relationship differed between younger (6–8 years) and older (9–12 years) children, and between female and male participants. Importantly, the older children drove the association between the CC mid-anterior and central subsection volumes and ToM abilities. This study is the first to demonstrate that CC size is associated with ToM abilities in healthy children, underlining the idea that the CC plays a vital role in their socio-cognitive development. CC subsection volumes may thus not only serve as a measure of heterogeneity in neurodevelopmental populations known to exhibit socio-cognitive deficits, but also in typically developing children. Oxford University Press 2023-10-11 /pmc/articles/PMC10690855/ /pubmed/37823275 http://dx.doi.org/10.1093/cercor/bhad353 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Mandl, Sophie Kienast, Patric Kollndorfer, Kathrin Kasprian, Gregor Weber, Michael Seidl, Rainer Bartha-Doering, Lisa Larger corpus callosum volume is favorable for theory of mind development in healthy children |
title | Larger corpus callosum volume is favorable for theory of mind development in healthy children |
title_full | Larger corpus callosum volume is favorable for theory of mind development in healthy children |
title_fullStr | Larger corpus callosum volume is favorable for theory of mind development in healthy children |
title_full_unstemmed | Larger corpus callosum volume is favorable for theory of mind development in healthy children |
title_short | Larger corpus callosum volume is favorable for theory of mind development in healthy children |
title_sort | larger corpus callosum volume is favorable for theory of mind development in healthy children |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690855/ https://www.ncbi.nlm.nih.gov/pubmed/37823275 http://dx.doi.org/10.1093/cercor/bhad353 |
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