Clonal hematopoiesis with DNMT3A and PPM1D mutations impairs regeneration in autologous stem cell transplant recipients

Clonal hematopoiesis (CH) is an age-related condition driven by stem and progenitor cells harboring recurrent mutations linked to myeloid neoplasms. Currently, potential effects on hematopoiesis, stem cell function and regenerative potential under stress conditions are unknown. We performed targeted...

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Detalles Bibliográficos
Autores principales: Stelmach, Patrick, Richter, Sarah, Sauer, Sandra, Fabre, Margarete A., Gu, Muxin, Rohde, Christian, Janssen, Maike, Liebers, Nora, Proynova, Rumyana, Weinhold, Niels, Raab, Marc S., Goldschmidt, Hartmut, Besenbeck, Birgit, Pavel, Petra, Laier, Sascha, Trumpp, Andreas, Dietrich, Sascha, Vassiliou, George S., Müller-Tidow, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2023
Materias:
Article - Hematopoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690900/
https://www.ncbi.nlm.nih.gov/pubmed/37381752
http://dx.doi.org/10.3324/haematol.2023.282992

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