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Advancing food safety risk assessment in China: development of new approach methodologies (NAMs)

Novel techniques and methodologies are being developed to advance food safety risk assessment into the next-generation. Considering the shortcomings of traditional animal testing, new approach methodologies (NAMs) will be the main tools for the next-generation risk assessment (NGRA), using non-anima...

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Autores principales: Yang, Daoyuan, Yang, Hui, Shi, Miaoying, Jia, Xudong, Sui, Haixia, Liu, Zhaoping, Wu, Yongning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690935/
https://www.ncbi.nlm.nih.gov/pubmed/38046399
http://dx.doi.org/10.3389/ftox.2023.1292373
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author Yang, Daoyuan
Yang, Hui
Shi, Miaoying
Jia, Xudong
Sui, Haixia
Liu, Zhaoping
Wu, Yongning
author_facet Yang, Daoyuan
Yang, Hui
Shi, Miaoying
Jia, Xudong
Sui, Haixia
Liu, Zhaoping
Wu, Yongning
author_sort Yang, Daoyuan
collection PubMed
description Novel techniques and methodologies are being developed to advance food safety risk assessment into the next-generation. Considering the shortcomings of traditional animal testing, new approach methodologies (NAMs) will be the main tools for the next-generation risk assessment (NGRA), using non-animal methodologies such as in vitro and in silico approaches. The United States Environmental Protection Agency and the European Food Safety Authority have established work plans to encourage the development and application of NAMs in NGRA. Currently, NAMs are more commonly used in research than in regulatory risk assessment. China is also developing NAMs for NGRA but without a comprehensive review of the current work. This review summarizes major NAM-related research articles from China and highlights the China National Center for Food Safety Risk Assessment (CFSA) as the primary institution leading the implementation of NAMs in NGRA in China. The projects of CFSA on NAMs such as the Food Toxicology Program and the strategies for implementing NAMs in NGRA are outlined. Key issues and recommendations, such as discipline development and team building, are also presented to promote NAMs development in China and worldwide.
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spelling pubmed-106909352023-12-02 Advancing food safety risk assessment in China: development of new approach methodologies (NAMs) Yang, Daoyuan Yang, Hui Shi, Miaoying Jia, Xudong Sui, Haixia Liu, Zhaoping Wu, Yongning Front Toxicol Toxicology Novel techniques and methodologies are being developed to advance food safety risk assessment into the next-generation. Considering the shortcomings of traditional animal testing, new approach methodologies (NAMs) will be the main tools for the next-generation risk assessment (NGRA), using non-animal methodologies such as in vitro and in silico approaches. The United States Environmental Protection Agency and the European Food Safety Authority have established work plans to encourage the development and application of NAMs in NGRA. Currently, NAMs are more commonly used in research than in regulatory risk assessment. China is also developing NAMs for NGRA but without a comprehensive review of the current work. This review summarizes major NAM-related research articles from China and highlights the China National Center for Food Safety Risk Assessment (CFSA) as the primary institution leading the implementation of NAMs in NGRA in China. The projects of CFSA on NAMs such as the Food Toxicology Program and the strategies for implementing NAMs in NGRA are outlined. Key issues and recommendations, such as discipline development and team building, are also presented to promote NAMs development in China and worldwide. Frontiers Media S.A. 2023-11-17 /pmc/articles/PMC10690935/ /pubmed/38046399 http://dx.doi.org/10.3389/ftox.2023.1292373 Text en Copyright © 2023 Yang, Yang, Shi, Jia, Sui, Liu and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Toxicology
Yang, Daoyuan
Yang, Hui
Shi, Miaoying
Jia, Xudong
Sui, Haixia
Liu, Zhaoping
Wu, Yongning
Advancing food safety risk assessment in China: development of new approach methodologies (NAMs)
title Advancing food safety risk assessment in China: development of new approach methodologies (NAMs)
title_full Advancing food safety risk assessment in China: development of new approach methodologies (NAMs)
title_fullStr Advancing food safety risk assessment in China: development of new approach methodologies (NAMs)
title_full_unstemmed Advancing food safety risk assessment in China: development of new approach methodologies (NAMs)
title_short Advancing food safety risk assessment in China: development of new approach methodologies (NAMs)
title_sort advancing food safety risk assessment in china: development of new approach methodologies (nams)
topic Toxicology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690935/
https://www.ncbi.nlm.nih.gov/pubmed/38046399
http://dx.doi.org/10.3389/ftox.2023.1292373
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