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Renal CIC-LEUTX rearranged sarcoma with multiple pulmonary metastases: a case report and literature review
BACKGROUND: CIC-rearranged sarcomas (CRS) are a group of heterogeneous tumors which mostly occur in the soft tissues of limbs and trunk, and are highly invasive with poor prognosis. Here, we describe a rare case of CRS that occurred in the left kidney with a CIC-LEUTX rearrangement. CASE PRESENTATIO...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691010/ https://www.ncbi.nlm.nih.gov/pubmed/38036973 http://dx.doi.org/10.1186/s12882-023-03404-x |
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author | Tang, Ying Lu, Xialiang Zhan, Rui |
author_facet | Tang, Ying Lu, Xialiang Zhan, Rui |
author_sort | Tang, Ying |
collection | PubMed |
description | BACKGROUND: CIC-rearranged sarcomas (CRS) are a group of heterogeneous tumors which mostly occur in the soft tissues of limbs and trunk, and are highly invasive with poor prognosis. Here, we describe a rare case of CRS that occurred in the left kidney with a CIC-LEUTX rearrangement. CASE PRESENTATION: A 45-year-old male was admitted to hospital with a dry cough for more than two months without obvious cause. Physical examination and laboratory tests revealed no notable abnormality. The CT scan demonstrated a mass in the left kidney and multiple nodules in both lungs. The percutaneous core needle biopsy showed similar histomorphology and immunophenotype of small round cell malignant tumors. Genetic test revealed a CIC-LEUTX gene fusion. CONCLUSIONS: We present a rare primary renal CRS with multiple pulmonary metastases, and LEUTX is confirmed as the fusion partner of CIC gene for the first time in a renal case. |
format | Online Article Text |
id | pubmed-10691010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-106910102023-12-02 Renal CIC-LEUTX rearranged sarcoma with multiple pulmonary metastases: a case report and literature review Tang, Ying Lu, Xialiang Zhan, Rui BMC Nephrol Case Report BACKGROUND: CIC-rearranged sarcomas (CRS) are a group of heterogeneous tumors which mostly occur in the soft tissues of limbs and trunk, and are highly invasive with poor prognosis. Here, we describe a rare case of CRS that occurred in the left kidney with a CIC-LEUTX rearrangement. CASE PRESENTATION: A 45-year-old male was admitted to hospital with a dry cough for more than two months without obvious cause. Physical examination and laboratory tests revealed no notable abnormality. The CT scan demonstrated a mass in the left kidney and multiple nodules in both lungs. The percutaneous core needle biopsy showed similar histomorphology and immunophenotype of small round cell malignant tumors. Genetic test revealed a CIC-LEUTX gene fusion. CONCLUSIONS: We present a rare primary renal CRS with multiple pulmonary metastases, and LEUTX is confirmed as the fusion partner of CIC gene for the first time in a renal case. BioMed Central 2023-11-30 /pmc/articles/PMC10691010/ /pubmed/38036973 http://dx.doi.org/10.1186/s12882-023-03404-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Tang, Ying Lu, Xialiang Zhan, Rui Renal CIC-LEUTX rearranged sarcoma with multiple pulmonary metastases: a case report and literature review |
title | Renal CIC-LEUTX rearranged sarcoma with multiple pulmonary metastases: a case report and literature review |
title_full | Renal CIC-LEUTX rearranged sarcoma with multiple pulmonary metastases: a case report and literature review |
title_fullStr | Renal CIC-LEUTX rearranged sarcoma with multiple pulmonary metastases: a case report and literature review |
title_full_unstemmed | Renal CIC-LEUTX rearranged sarcoma with multiple pulmonary metastases: a case report and literature review |
title_short | Renal CIC-LEUTX rearranged sarcoma with multiple pulmonary metastases: a case report and literature review |
title_sort | renal cic-leutx rearranged sarcoma with multiple pulmonary metastases: a case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691010/ https://www.ncbi.nlm.nih.gov/pubmed/38036973 http://dx.doi.org/10.1186/s12882-023-03404-x |
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