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Muscle quality index and cardiovascular disease among US population-findings from NHANES 2011–2014

BACKGROUND AND OBJECTIVE: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States. However, current evidence on the association between muscle quality and CVD is limited. This study investigates the potential association between the muscle quality index (MQI...

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Autores principales: Chen, Yanlin, Lin, Weidong, Fu, Lu, Liu, Huiyi, Jin, Shuyu, Ye, Xingdong, Pu, Sijia, Xue, Yumei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691039/
https://www.ncbi.nlm.nih.gov/pubmed/38041010
http://dx.doi.org/10.1186/s12889-023-17303-1
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author Chen, Yanlin
Lin, Weidong
Fu, Lu
Liu, Huiyi
Jin, Shuyu
Ye, Xingdong
Pu, Sijia
Xue, Yumei
author_facet Chen, Yanlin
Lin, Weidong
Fu, Lu
Liu, Huiyi
Jin, Shuyu
Ye, Xingdong
Pu, Sijia
Xue, Yumei
author_sort Chen, Yanlin
collection PubMed
description BACKGROUND AND OBJECTIVE: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States. However, current evidence on the association between muscle quality and CVD is limited. This study investigates the potential association between the muscle quality index (MQI) and the prevalence of CVD and CVD-related mortality. METHODS: Participants were selected from the National Health and Nutrition Examination Survey (NHANES) 2011–2014. Data on mortality and causes of death were obtained from the National Death Index (NDI) records through December 31, 2019. Statistical analysis used in this study, including weighted multivariable linear and logistic regression, cox regression and Kaplan-Meier (K-M) analysis, to estimate the association between MQI and all-cause mortality as well as CVD mortality. In addition, subgroup analysis was used to estimate the association between MQI and CVD subtypes, such as heart attack, coronary heart disease, angina, congestive heart failure, and stroke. RESULTS: A total of 5,053 participants were included in the final analysis. Weighted multivariable linear regression models revealed that a lower MQI.total level was independently associated with an increased risk of CVD development in model 3, with t value =-3.48, 95%CI: (-0.24, -0.06), P = 0.002. During 5,053 person-years of 6.92 years of follow-up, there were 29 deaths from CVD. Still, the association between MQI.total and CVD mortality, as well as all-cause mortality did not reach statistical significance in the fully adjusted model (HR = 0.58, 95% CI: 0.21–1.62, P = 0.30; HR = 0.91, 95% CI:0.65,1.28, P = 0.59, respectively). Subgroup analysis confirmed that MQI.total was negatively associated with congestive heart failure (OR = 0.35, 95% CI = 0.18,0.68, P = 0.01). CONCLUSION: This study highlights the potential of MQI as a measure of muscle quality, its negative correlation with congestive heart failure (CHF). However, MQI was not very useful for predicting the health outcomes such as CVD and mortality. Therefore, more attention should be paid to the early recognition of muscle weakness progression in CHF. Further studies are needed to explore more effective indicator to evaluate the association between muscle quality and health outcomes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-023-17303-1.
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spelling pubmed-106910392023-12-02 Muscle quality index and cardiovascular disease among US population-findings from NHANES 2011–2014 Chen, Yanlin Lin, Weidong Fu, Lu Liu, Huiyi Jin, Shuyu Ye, Xingdong Pu, Sijia Xue, Yumei BMC Public Health Research BACKGROUND AND OBJECTIVE: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States. However, current evidence on the association between muscle quality and CVD is limited. This study investigates the potential association between the muscle quality index (MQI) and the prevalence of CVD and CVD-related mortality. METHODS: Participants were selected from the National Health and Nutrition Examination Survey (NHANES) 2011–2014. Data on mortality and causes of death were obtained from the National Death Index (NDI) records through December 31, 2019. Statistical analysis used in this study, including weighted multivariable linear and logistic regression, cox regression and Kaplan-Meier (K-M) analysis, to estimate the association between MQI and all-cause mortality as well as CVD mortality. In addition, subgroup analysis was used to estimate the association between MQI and CVD subtypes, such as heart attack, coronary heart disease, angina, congestive heart failure, and stroke. RESULTS: A total of 5,053 participants were included in the final analysis. Weighted multivariable linear regression models revealed that a lower MQI.total level was independently associated with an increased risk of CVD development in model 3, with t value =-3.48, 95%CI: (-0.24, -0.06), P = 0.002. During 5,053 person-years of 6.92 years of follow-up, there were 29 deaths from CVD. Still, the association between MQI.total and CVD mortality, as well as all-cause mortality did not reach statistical significance in the fully adjusted model (HR = 0.58, 95% CI: 0.21–1.62, P = 0.30; HR = 0.91, 95% CI:0.65,1.28, P = 0.59, respectively). Subgroup analysis confirmed that MQI.total was negatively associated with congestive heart failure (OR = 0.35, 95% CI = 0.18,0.68, P = 0.01). CONCLUSION: This study highlights the potential of MQI as a measure of muscle quality, its negative correlation with congestive heart failure (CHF). However, MQI was not very useful for predicting the health outcomes such as CVD and mortality. Therefore, more attention should be paid to the early recognition of muscle weakness progression in CHF. Further studies are needed to explore more effective indicator to evaluate the association between muscle quality and health outcomes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-023-17303-1. BioMed Central 2023-12-01 /pmc/articles/PMC10691039/ /pubmed/38041010 http://dx.doi.org/10.1186/s12889-023-17303-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Chen, Yanlin
Lin, Weidong
Fu, Lu
Liu, Huiyi
Jin, Shuyu
Ye, Xingdong
Pu, Sijia
Xue, Yumei
Muscle quality index and cardiovascular disease among US population-findings from NHANES 2011–2014
title Muscle quality index and cardiovascular disease among US population-findings from NHANES 2011–2014
title_full Muscle quality index and cardiovascular disease among US population-findings from NHANES 2011–2014
title_fullStr Muscle quality index and cardiovascular disease among US population-findings from NHANES 2011–2014
title_full_unstemmed Muscle quality index and cardiovascular disease among US population-findings from NHANES 2011–2014
title_short Muscle quality index and cardiovascular disease among US population-findings from NHANES 2011–2014
title_sort muscle quality index and cardiovascular disease among us population-findings from nhanes 2011–2014
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691039/
https://www.ncbi.nlm.nih.gov/pubmed/38041010
http://dx.doi.org/10.1186/s12889-023-17303-1
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