Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus

Lung tissue is an important organ of the fetus, and genomic research on its development has improved our understanding of the biology of this tissue. However, the proteomic research of developing fetal lung tissue is still very scarce. We conducted comprehensive analysis of two developmental stages...

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Autores principales: Wang, Wei, Shi, Wei, Wang, Yinglan, Yang, Yane, Li, Ping, Zeng, Zhipeng, Hu, Wenlong, Chen, Yumei, Tang, Donge, Dai, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691156/
https://www.ncbi.nlm.nih.gov/pubmed/38041078
http://dx.doi.org/10.1186/s12953-023-00215-8
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author Wang, Wei
Shi, Wei
Wang, Yinglan
Yang, Yane
Li, Ping
Zeng, Zhipeng
Hu, Wenlong
Chen, Yumei
Tang, Donge
Dai, Yong
author_facet Wang, Wei
Shi, Wei
Wang, Yinglan
Yang, Yane
Li, Ping
Zeng, Zhipeng
Hu, Wenlong
Chen, Yumei
Tang, Donge
Dai, Yong
author_sort Wang, Wei
collection PubMed
description Lung tissue is an important organ of the fetus, and genomic research on its development has improved our understanding of the biology of this tissue. However, the proteomic research of developing fetal lung tissue is still very scarce. We conducted comprehensive analysis of two developmental stages of fetal lung tissue of proteomics. It showed the developmental characteristics of lung tissue, such as the down-regulation of metabolism-related protein expression, the up-regulation of cell cycle-related proteins, and the regulation in proteins and pathways related to lung development. In addition, we also discovered some key core proteins related to lung development, and provided some key crotonylation modification sites that regulation during lung tissue development. Our comprehensive analysis of lung proteomics can provide a more comprehensive understanding of the developmental status of lung tissue, and provide a certain reference for future research and epigenetics of lung tissue. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12953-023-00215-8.
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spelling pubmed-106911562023-12-02 Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus Wang, Wei Shi, Wei Wang, Yinglan Yang, Yane Li, Ping Zeng, Zhipeng Hu, Wenlong Chen, Yumei Tang, Donge Dai, Yong Proteome Sci Research Lung tissue is an important organ of the fetus, and genomic research on its development has improved our understanding of the biology of this tissue. However, the proteomic research of developing fetal lung tissue is still very scarce. We conducted comprehensive analysis of two developmental stages of fetal lung tissue of proteomics. It showed the developmental characteristics of lung tissue, such as the down-regulation of metabolism-related protein expression, the up-regulation of cell cycle-related proteins, and the regulation in proteins and pathways related to lung development. In addition, we also discovered some key core proteins related to lung development, and provided some key crotonylation modification sites that regulation during lung tissue development. Our comprehensive analysis of lung proteomics can provide a more comprehensive understanding of the developmental status of lung tissue, and provide a certain reference for future research and epigenetics of lung tissue. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12953-023-00215-8. BioMed Central 2023-12-01 /pmc/articles/PMC10691156/ /pubmed/38041078 http://dx.doi.org/10.1186/s12953-023-00215-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Wei
Shi, Wei
Wang, Yinglan
Yang, Yane
Li, Ping
Zeng, Zhipeng
Hu, Wenlong
Chen, Yumei
Tang, Donge
Dai, Yong
Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus
title Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus
title_full Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus
title_fullStr Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus
title_full_unstemmed Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus
title_short Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus
title_sort systematic proteomics profiling of lysine crotonylation of the lung at pseudoglandular and canalicular phases in human fetus
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691156/
https://www.ncbi.nlm.nih.gov/pubmed/38041078
http://dx.doi.org/10.1186/s12953-023-00215-8
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