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The expression and clinical significance of PLK1/p-PLK1 protein in NK/T cell Lymphoma

AIMS: To investigate the expression of polo-like kinase 1 protein (PLK1) and its phosphorylation level (p-PLK1) in extranodal NK/T cell lymphoma (NKTCL) and their correlation with clinical characteristics and prognosis. METHODS: We collected 40 cases of NKTCL (referred to as the experimental group),...

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Autores principales: Zhang, Zhiqi, Liu, Enjie, Zhang, Dandan, Zhao, Wugan, Wang, Guannan, Zhang, Yanping, Huo, Yajun, Zhang, Chongli, Li, Wencai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691161/
https://www.ncbi.nlm.nih.gov/pubmed/38037110
http://dx.doi.org/10.1186/s13000-023-01413-w
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author Zhang, Zhiqi
Liu, Enjie
Zhang, Dandan
Zhao, Wugan
Wang, Guannan
Zhang, Yanping
Huo, Yajun
Zhang, Chongli
Li, Wencai
author_facet Zhang, Zhiqi
Liu, Enjie
Zhang, Dandan
Zhao, Wugan
Wang, Guannan
Zhang, Yanping
Huo, Yajun
Zhang, Chongli
Li, Wencai
author_sort Zhang, Zhiqi
collection PubMed
description AIMS: To investigate the expression of polo-like kinase 1 protein (PLK1) and its phosphorylation level (p-PLK1) in extranodal NK/T cell lymphoma (NKTCL) and their correlation with clinical characteristics and prognosis. METHODS: We collected 40 cases of NKTCL (referred to as the experimental group), which received diagnoses at the First Affiliated Hospital of Zhengzhou University between January 2018 and October 2022. Concurrently, we assembled a control group, including 20 cases afflicted with nasopharyngeal mucosal lymphoid hyperplasia diseases during the same timeframe. We utilized immunohistochemical techniques to evaluate the levels of PLK1 and p-PLK1 expression in both the experimental and control groups. Subsequently, we conducted an analysis to identify disparities in their expression and explore their relationships with clinical characteristics and patient prognosis. RESULTS: Among the 40 NKTCL patients, there were 27 males and 11 females, with a median age of 51 years (range 12–80 years). Compared to the control group, the tissue samples of NKTCL patients exhibited significantly elevated expression levels and active phosphorylation levels of PLK1 (P < 0.05). Correlation analysis of the immunohistochemical H score and Ki-67 positive rate of PLK1 and p-PLK1, revealed a significant positive correlation for both (P < 0.0001, each). No statistically significant differences were observed in the distribution of PLK1 and p-PLK1 expression in NKTCL patients with respect to gender, age, Ann Arbor stage, PINK-E score, B-symptoms, lactate dehydrogenase, β2-microglobulin, blood EBV-DNA, bone marrow invasion, and lymph node metastasis (p > 0.05). Grouping based on PLK1 and p-PLK1 immunohistochemical H-scores revealed that the high expression of PLK1 and p-PLK1 was associated with poor prognosis. CONCLUSIONS: The expression levels and active phosphorylation levels of PLK1 were significantly increased in NK/T cell lymphoma, and patients with overexpression of PLK1 and p-PLK1 had a poorer prognosis.
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spelling pubmed-106911612023-12-02 The expression and clinical significance of PLK1/p-PLK1 protein in NK/T cell Lymphoma Zhang, Zhiqi Liu, Enjie Zhang, Dandan Zhao, Wugan Wang, Guannan Zhang, Yanping Huo, Yajun Zhang, Chongli Li, Wencai Diagn Pathol Research AIMS: To investigate the expression of polo-like kinase 1 protein (PLK1) and its phosphorylation level (p-PLK1) in extranodal NK/T cell lymphoma (NKTCL) and their correlation with clinical characteristics and prognosis. METHODS: We collected 40 cases of NKTCL (referred to as the experimental group), which received diagnoses at the First Affiliated Hospital of Zhengzhou University between January 2018 and October 2022. Concurrently, we assembled a control group, including 20 cases afflicted with nasopharyngeal mucosal lymphoid hyperplasia diseases during the same timeframe. We utilized immunohistochemical techniques to evaluate the levels of PLK1 and p-PLK1 expression in both the experimental and control groups. Subsequently, we conducted an analysis to identify disparities in their expression and explore their relationships with clinical characteristics and patient prognosis. RESULTS: Among the 40 NKTCL patients, there were 27 males and 11 females, with a median age of 51 years (range 12–80 years). Compared to the control group, the tissue samples of NKTCL patients exhibited significantly elevated expression levels and active phosphorylation levels of PLK1 (P < 0.05). Correlation analysis of the immunohistochemical H score and Ki-67 positive rate of PLK1 and p-PLK1, revealed a significant positive correlation for both (P < 0.0001, each). No statistically significant differences were observed in the distribution of PLK1 and p-PLK1 expression in NKTCL patients with respect to gender, age, Ann Arbor stage, PINK-E score, B-symptoms, lactate dehydrogenase, β2-microglobulin, blood EBV-DNA, bone marrow invasion, and lymph node metastasis (p > 0.05). Grouping based on PLK1 and p-PLK1 immunohistochemical H-scores revealed that the high expression of PLK1 and p-PLK1 was associated with poor prognosis. CONCLUSIONS: The expression levels and active phosphorylation levels of PLK1 were significantly increased in NK/T cell lymphoma, and patients with overexpression of PLK1 and p-PLK1 had a poorer prognosis. BioMed Central 2023-11-30 /pmc/articles/PMC10691161/ /pubmed/38037110 http://dx.doi.org/10.1186/s13000-023-01413-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zhang, Zhiqi
Liu, Enjie
Zhang, Dandan
Zhao, Wugan
Wang, Guannan
Zhang, Yanping
Huo, Yajun
Zhang, Chongli
Li, Wencai
The expression and clinical significance of PLK1/p-PLK1 protein in NK/T cell Lymphoma
title The expression and clinical significance of PLK1/p-PLK1 protein in NK/T cell Lymphoma
title_full The expression and clinical significance of PLK1/p-PLK1 protein in NK/T cell Lymphoma
title_fullStr The expression and clinical significance of PLK1/p-PLK1 protein in NK/T cell Lymphoma
title_full_unstemmed The expression and clinical significance of PLK1/p-PLK1 protein in NK/T cell Lymphoma
title_short The expression and clinical significance of PLK1/p-PLK1 protein in NK/T cell Lymphoma
title_sort expression and clinical significance of plk1/p-plk1 protein in nk/t cell lymphoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691161/
https://www.ncbi.nlm.nih.gov/pubmed/38037110
http://dx.doi.org/10.1186/s13000-023-01413-w
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