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The mechanism of Gα(q) regulation of PLCβ3-catalyzed PIP2 hydrolysis
PLCβ (Phospholipase Cβ) enzymes cleave phosphatidylinositol 4,5-bisphosphate (PIP2) producing IP3 and DAG (diacylglycerol). PIP2 modulates the function of many ion channels, while IP3 and DAG regulate intracellular Ca(2+) levels and protein phosphorylation by protein kinase C, respectively. PLCβ enz...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691244/ https://www.ncbi.nlm.nih.gov/pubmed/37991948 http://dx.doi.org/10.1073/pnas.2315011120 |