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Histological characteristics of hair follicles at different hair cycle and in vitro modeling of hair follicle-associated cells of yak (Bos grunniens)
To adapt to the extreme conditions of plateau environments, yaks have evolved thick hair, making them an ideal model for investigating the mechanisms involved in hair growth. We can gain valuable insights into how hair follicles develop and their cyclic growth in challenging environments by studying...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691264/ https://www.ncbi.nlm.nih.gov/pubmed/38046572 http://dx.doi.org/10.3389/fvets.2023.1277586 |
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author | Liao, Bo Cui, Yan Yu, Sijiu He, Junfeng Yang, Xue Zou, Shengnan Li, Sijie Zhao, Pengfei Xu, Hongwei Long, Min Wang, Xiaoyan |
author_facet | Liao, Bo Cui, Yan Yu, Sijiu He, Junfeng Yang, Xue Zou, Shengnan Li, Sijie Zhao, Pengfei Xu, Hongwei Long, Min Wang, Xiaoyan |
author_sort | Liao, Bo |
collection | PubMed |
description | To adapt to the extreme conditions of plateau environments, yaks have evolved thick hair, making them an ideal model for investigating the mechanisms involved in hair growth. We can gain valuable insights into how hair follicles develop and their cyclic growth in challenging environments by studying yaks. However, the lack of essential data on yak hair follicle histology and the absence of in vitro cell models for hair follicles serve as a limitation to such research objectives. In this study, we investigated the structure of skin tissue during different hair follicle cycles using the yak model. Additionally, we successfully established in vitro models of hair follicle-associated cells derived from yak skin, including dermal papilla cells (DPCs), preadipocytes, and fibroblasts. We optimized the microdissection technique for DPCs culture by simplifying the procedure and reducing the time required. Furthermore, we improved the methodology used to differentiate yak preadipocytes into mature adipocytes, thus increasing the differentiation efficiency. The introduction of yak as a natural model provides valuable research resources for exploring the mechanisms of hair growth and contributes to a deeper understanding of hair follicle biology and the development of regenerative medicine strategies. |
format | Online Article Text |
id | pubmed-10691264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106912642023-12-02 Histological characteristics of hair follicles at different hair cycle and in vitro modeling of hair follicle-associated cells of yak (Bos grunniens) Liao, Bo Cui, Yan Yu, Sijiu He, Junfeng Yang, Xue Zou, Shengnan Li, Sijie Zhao, Pengfei Xu, Hongwei Long, Min Wang, Xiaoyan Front Vet Sci Veterinary Science To adapt to the extreme conditions of plateau environments, yaks have evolved thick hair, making them an ideal model for investigating the mechanisms involved in hair growth. We can gain valuable insights into how hair follicles develop and their cyclic growth in challenging environments by studying yaks. However, the lack of essential data on yak hair follicle histology and the absence of in vitro cell models for hair follicles serve as a limitation to such research objectives. In this study, we investigated the structure of skin tissue during different hair follicle cycles using the yak model. Additionally, we successfully established in vitro models of hair follicle-associated cells derived from yak skin, including dermal papilla cells (DPCs), preadipocytes, and fibroblasts. We optimized the microdissection technique for DPCs culture by simplifying the procedure and reducing the time required. Furthermore, we improved the methodology used to differentiate yak preadipocytes into mature adipocytes, thus increasing the differentiation efficiency. The introduction of yak as a natural model provides valuable research resources for exploring the mechanisms of hair growth and contributes to a deeper understanding of hair follicle biology and the development of regenerative medicine strategies. Frontiers Media S.A. 2023-11-17 /pmc/articles/PMC10691264/ /pubmed/38046572 http://dx.doi.org/10.3389/fvets.2023.1277586 Text en Copyright © 2023 Liao, Cui, Yu, He, Yang, Zou, Li, Zhao, Xu, Long and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Liao, Bo Cui, Yan Yu, Sijiu He, Junfeng Yang, Xue Zou, Shengnan Li, Sijie Zhao, Pengfei Xu, Hongwei Long, Min Wang, Xiaoyan Histological characteristics of hair follicles at different hair cycle and in vitro modeling of hair follicle-associated cells of yak (Bos grunniens) |
title | Histological characteristics of hair follicles at different hair cycle and in vitro modeling of hair follicle-associated cells of yak (Bos grunniens) |
title_full | Histological characteristics of hair follicles at different hair cycle and in vitro modeling of hair follicle-associated cells of yak (Bos grunniens) |
title_fullStr | Histological characteristics of hair follicles at different hair cycle and in vitro modeling of hair follicle-associated cells of yak (Bos grunniens) |
title_full_unstemmed | Histological characteristics of hair follicles at different hair cycle and in vitro modeling of hair follicle-associated cells of yak (Bos grunniens) |
title_short | Histological characteristics of hair follicles at different hair cycle and in vitro modeling of hair follicle-associated cells of yak (Bos grunniens) |
title_sort | histological characteristics of hair follicles at different hair cycle and in vitro modeling of hair follicle-associated cells of yak (bos grunniens) |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691264/ https://www.ncbi.nlm.nih.gov/pubmed/38046572 http://dx.doi.org/10.3389/fvets.2023.1277586 |
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