ADAR1 Zα domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing

Variants of the RNA-editing enzyme ADAR1 cause Aicardi-Goutières syndrome (AGS), in which severe inflammation occurs in the brain due to innate immune activation. Here, we analyze the RNA-editing status and innate immune activation in an AGS mouse model that carries the Adar P195A mutation in the N...

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Detalles Bibliográficos
Autores principales: Guo, Xinfeng, Liu, Silvia, Sheng, Yi, Zenati, Mazen, Billiar, Timothy, Herbert, Alan, Wang, Qingde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691306/
https://www.ncbi.nlm.nih.gov/pubmed/37421629
http://dx.doi.org/10.1016/j.celrep.2023.112733

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