Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity

Constitutive activation of the MALT1 paracaspase in conventional T cells of Malt1(TBM/TBM) (TRAF6 Binding Mutant = TBM) mice causes fatal inflammation and autoimmunity, but the involved targets and underlying molecular mechanisms are unknown. We genetically rendered a single MALT1 substrate, the RNA...

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Detalles Bibliográficos
Autores principales: Schmidt, Henrik, Raj, Timsse, O'Neill, Thomas J., Muschaweckh, Andreas, Giesert, Florian, Negraschus, Arlinda, Hoefig, Kai P., Behrens, Gesine, Esser, Lena, Baumann, Christina, Feederle, Regina, Plaza-Sirvent, Carlos, Geerlof, Arie, Gewies, Andreas, Isay, Sophie E., Ruland, Jürgen, Schmitz, Ingo, Wurst, Wolfgang, Korn, Thomas, Krappmann, Daniel, Heissmeyer, Vigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691344/
https://www.ncbi.nlm.nih.gov/pubmed/37988467
http://dx.doi.org/10.1073/pnas.2309205120

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