RAD51-mediated R-loop formation acts to repair transcription-associated DNA breaks driving antigenic variation in Trypanosoma brucei

RNA–DNA hybrids are epigenetic features of all genomes that intersect with many processes, including transcription, telomere homeostasis, and centromere function. Increasing evidence suggests that RNA–DNA hybrids can provide two conflicting roles in the maintenance and transmission of genomes: They...

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Detalles Bibliográficos
Autores principales: Girasol, Mark John, Krasilnikova, Marija, Marques, Catarina A., Damasceno, Jeziel D., Lapsley, Craig, Lemgruber, Leandro, Burchmore, Richard, Beraldi, Dario, Carruthers, Ross, Briggs, Emma M., McCulloch, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691351/
https://www.ncbi.nlm.nih.gov/pubmed/37988471
http://dx.doi.org/10.1073/pnas.2309306120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691351/
https://www.ncbi.nlm.nih.gov/pubmed/37988471
http://dx.doi.org/10.1073/pnas.2309306120

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