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Monitoring of antibody levels in healthcare workers after inactivated coronavirus disease 19 vaccination

OBJECTIVE: Because of the coronavirus disease 19 pandemic, studies on vaccination are being conducted in our country as well as across the world. In this study, the antibody levels in healthcare workers vaccinated with two doses of inactivated vaccine and the factors affecting these levels were inve...

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Autores principales: Çalişkan, Emel, Öztürk, Cihadiye Elif, Öksüz, Şükrü, Ince, Nevin, Yekenkurul, Dilek, Kahraman, Gözde, Duran, Pelin, Şahin, İdris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Médica Brasileira 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691365/
http://dx.doi.org/10.1590/1806-9282.20220766
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author Çalişkan, Emel
Öztürk, Cihadiye Elif
Öksüz, Şükrü
Ince, Nevin
Yekenkurul, Dilek
Kahraman, Gözde
Duran, Pelin
Şahin, İdris
author_facet Çalişkan, Emel
Öztürk, Cihadiye Elif
Öksüz, Şükrü
Ince, Nevin
Yekenkurul, Dilek
Kahraman, Gözde
Duran, Pelin
Şahin, İdris
author_sort Çalişkan, Emel
collection PubMed
description OBJECTIVE: Because of the coronavirus disease 19 pandemic, studies on vaccination are being conducted in our country as well as across the world. In this study, the antibody levels in healthcare workers vaccinated with two doses of inactivated vaccine and the factors affecting these levels were investigated. METHODS: Randomly selected volunteers from healthcare workers, who had been vaccinated with two doses of inactivated vaccine in January to February 2021, were included in the study. Blood samples were drawn twice, 1 month and 6 months after the second dose vaccine (CoronaVac:Sinovac Life Science Co, Ltd, Beijing, China). The antibody levels were determined by the chemiluminescence microparticle immunoassay method using kits for quantitative detection of immunoglobulin class G antibodies to severe acute respiratory syndrome coronavirus 2. RESULTS: The mean antibody levels of 129 volunteers were 1232.5 (min: 103 to max: 7151) AU/mL in the first month and 403.5 (min: 23 to max: 4963) AU/mL in the sixth month. According to the survey results, 91 (71%) volunteers had not been diagnosed with coronavirus disease 19 before vaccination. The antibody levels 1 month and 6 months after the second dose of vaccination were significantly higher in those who had been diagnosed with coronavirus disease 19 before vaccination than in those who had not. It was found that age, gender, fast food, or healthy nutrition had no effect on antibody levels. CONCLUSION: Vaccines are very important both to protect against coronavirus disease 19 and to experience only a mild form of the disease. Immunoglobulin class G levels formed after vaccination may be affected by many factors and may decrease over time.
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spelling pubmed-106913652023-12-02 Monitoring of antibody levels in healthcare workers after inactivated coronavirus disease 19 vaccination Çalişkan, Emel Öztürk, Cihadiye Elif Öksüz, Şükrü Ince, Nevin Yekenkurul, Dilek Kahraman, Gözde Duran, Pelin Şahin, İdris Rev Assoc Med Bras (1992) Original Article OBJECTIVE: Because of the coronavirus disease 19 pandemic, studies on vaccination are being conducted in our country as well as across the world. In this study, the antibody levels in healthcare workers vaccinated with two doses of inactivated vaccine and the factors affecting these levels were investigated. METHODS: Randomly selected volunteers from healthcare workers, who had been vaccinated with two doses of inactivated vaccine in January to February 2021, were included in the study. Blood samples were drawn twice, 1 month and 6 months after the second dose vaccine (CoronaVac:Sinovac Life Science Co, Ltd, Beijing, China). The antibody levels were determined by the chemiluminescence microparticle immunoassay method using kits for quantitative detection of immunoglobulin class G antibodies to severe acute respiratory syndrome coronavirus 2. RESULTS: The mean antibody levels of 129 volunteers were 1232.5 (min: 103 to max: 7151) AU/mL in the first month and 403.5 (min: 23 to max: 4963) AU/mL in the sixth month. According to the survey results, 91 (71%) volunteers had not been diagnosed with coronavirus disease 19 before vaccination. The antibody levels 1 month and 6 months after the second dose of vaccination were significantly higher in those who had been diagnosed with coronavirus disease 19 before vaccination than in those who had not. It was found that age, gender, fast food, or healthy nutrition had no effect on antibody levels. CONCLUSION: Vaccines are very important both to protect against coronavirus disease 19 and to experience only a mild form of the disease. Immunoglobulin class G levels formed after vaccination may be affected by many factors and may decrease over time. Associação Médica Brasileira 2023-11-24 /pmc/articles/PMC10691365/ http://dx.doi.org/10.1590/1806-9282.20220766 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Çalişkan, Emel
Öztürk, Cihadiye Elif
Öksüz, Şükrü
Ince, Nevin
Yekenkurul, Dilek
Kahraman, Gözde
Duran, Pelin
Şahin, İdris
Monitoring of antibody levels in healthcare workers after inactivated coronavirus disease 19 vaccination
title Monitoring of antibody levels in healthcare workers after inactivated coronavirus disease 19 vaccination
title_full Monitoring of antibody levels in healthcare workers after inactivated coronavirus disease 19 vaccination
title_fullStr Monitoring of antibody levels in healthcare workers after inactivated coronavirus disease 19 vaccination
title_full_unstemmed Monitoring of antibody levels in healthcare workers after inactivated coronavirus disease 19 vaccination
title_short Monitoring of antibody levels in healthcare workers after inactivated coronavirus disease 19 vaccination
title_sort monitoring of antibody levels in healthcare workers after inactivated coronavirus disease 19 vaccination
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691365/
http://dx.doi.org/10.1590/1806-9282.20220766
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